Third Annual BMRP Investigator Meeting

February 24-25, 2005
Los Angeles, California
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    Invited Speaker:
    Baltimore, David, Ph.D.
    Nobel Laureate in Physiology or Medicine President, California Institute of Technology (Pasadena, California, U.S.A.)

    "NF-kappaB and its role in inflammation"
    Scientific Summary of Meeting:
    Jewell, Derek, BM, BCh, DPhil
    University of Oxford (United Kingdom)
    Presentations By BMRP Investigators:
    (partial list of talks and posters)
    Ahmad, Tariq, M.B. Ch.B.
    University of Oxford (United Kingdom)

    "Loop ileostomy for Crohn's disease - molecular clues to disease pathogenesis"

    Abstract
    Anderson, James, M.D., Ph.D.
    University of North Carolina at Chapel Hill (U.S.A.)

    "The role of intestinal flora in transcriptional and functional control of the tight junction barrier"

    Abstract
    Baumgart, Daniel C., M.D.
    Charité Medical Center - Virchow Hospital (Germany)

    "Patients with active inflammatory bowel disease lack immature peripheral blood dendritic cells that show an aberrant response to microbial surrogate stimuli"

    Abstract
    Bienenstock, John, M.D.
    McMaster University (Hamilton, Ontario, Canada)

    "Is there a neurophysiologic basis for immunoregulation by probiotics?"
    Braun, Jonathan, M.D., Ph.D.
    University of California, Los Angeles (U.S.A.)

    "Intestinal fungal and bacterial composition of the murine intestine"

    Abstract
    Presentation
    Butler, Matthew, Ph.D.
    Imperial College London (United Kingdom)

    "Effect of dietary microparticles on macrophage function in Crohn's disease"

    Abstract
    Carrier, Ewa, M.D.
    University of California, San Diego (U.S.A.)

    "Repair of Crohn's disease with embryonic stem cells"

    Abstract
    Cartwright, Christine A., M.D.
    Stanford University (California, U.S.A.)

    "Ulcerative colitis: molecular mechanisms of carcinogenesis"
    Clancy, Robert, M.D., Ph.D.
    University of Newcastle (Australia)

    "Mycobacterium avium subspecies paratuberculosis - does it have a role in the pathogenesis of Crohn's disease?"

    Abstract
    Colman, Robert W., M.D.
    Temple University (Philadelphia, Pennsylvania, U.S.A.)

    "High molecular weight kininogen fragments stimulate the secretion of interleukin 1b through urokinase-type plasminogen activation receptor (uPAR) and CD11b/CD18 (Mac-1) in human blood monocytes"

    Abstract
    Cummins, Adrian, G., Ph.D., M.D.
    The Queen Elizabeth Hospital (Woodville South, Australia)

    "Deficiency of NK and CD1d restricted Va24+ NK T-cells in Crohn's disease and ulcerative colitis"

    Abstract
    Denson, Lee A., M.D.
    Cincinnati Children's Hospital Medical Center (Ohio, U.S.A.)

    "Immunomodulatory effects of growth hormone in experimental colitis"

    Abstract
    Florin, Timothy H. J., MBBS
    University of Queensland (South Brisbane, Australia)

    "Real-time PCR quantification of suspect bacteria in inflammatory bowel disease mucosa"

    Abstract
    Föll, Dirk, M.D.
    University of Münster (Germany)

    "The role of the pro-inflammatory mediator S100A12 in inflammatory bowel disease"

    Abstract
    Gewirtz, Andrew, Ph.D.
    Emory University (Atlanta, Georgia, U.S.A.)

    "Adaptive immunity to flagellin in inflammatory bowel disease"

    Presentation
    Ginsburg, Philip M., M.D.
    Johns Hopkins University (Baltimore, Maryland, U.S.A.)

    "Testing the homogeneity of the stenotic/stricturing phenotype in Crohn's disease utilizing PET/CT imaging"

    Abstract
    Greeley, George H., Jr., Ph.D.
    University of Texas at Galveston (U.S.A.)

    "Increased colonic apelin expression during experimental colitis in rodents and in humans with inflammatory bowel disease"

    Abstract
    Hale, Laura P., M.D., Ph.D.
    Duke University (Durham, North Carolina, U.S.A.)

    "Bromelain treatment of inflammatory bowel disease"

    Abstract
    Hanski, Christoph, Ph.D.
    Charité Universitätsmedizin Berlin Campus Benjamin Franklin (Germany)

    "Effects of deoxycholic acid and ursodeoxycholic acid on the development of carcinomas during murine chronic ulcerative colitis"

    Abstract
    Hebert, Steven C., M.D.
    Yale University (New Haven, Connecticut, U.S.A.)

    "Activation of the extracellular calcium (nutrient)-sensing receptor reduces the severity of acute and chronic DSS-induced injury"
    Holcombe, Randall F., M.D.
    University of California, Irvine (U.S.A.)

    "WNT signaling in inflammatory bowel disease-related colon cancer"

    Abstract
    Jobin, Christian, Ph.D.
    University of California, Los Angeles (U.S.A.)

    "The flavonoid luteolin prevents LPS-induced NF-kB signaling and gene expression by blocking IkB kinase activity in intestinal epithelial cells and bone marrow-derived dendritic cells"

    Abstract
    Presentation
    Kobayashi, Koichi, M.D., Ph.D.
    Harvard University (Boston, Massachusetts, U.S.A.)

    "A role of innate immunity in the pathogenesis of inflammatory bowel disease"

    Abstract
    Koide, Yukio, M.D., Ph.D.
    Hamamatsu University School of Medicine (Japan)

    "A randomized clinical trial of curcumin in the maintenance therapy of ulcerative colitis"

    Abstract
    Presentation
    Kucharzik, Torsten F., M.D.
    University of Münster (Germany)

    "Anti-inflammatory activity of the a-MSH and its tripeptide KPV in inflammatory bowel disease animal models"
    Lamps, Laura W., M.D.
    University of Arkansas for Medical Sciences (Little Rock, U.S.A.)

    "Pathogenic Yersinia DNA detection in Crohn's disease"

    Abstract
    Leiter, Edward H., Ph.D.
    The Jackson Laboratory (Bar Harbor, Maine, U.S.A.)

    "Cdcs1, a major colitis susceptibility gene in mice, regulates innate and adaptive immune response to enteric bacterial antigens"

    Abstract
    Leung, Euphemia, Ph.D.
    University of Auckland (New Zealand)

    "Alternative splicing of NOD2 (CARD15) RNA transcripts as a means of regulating the expression of human NOD2"

    "Polymorphisms of CARD15/NOD2 and CD14 genes in New Zealand Crohn's disease patients"
    Li, Xuhang, Ph.D.
    Johns Hopkins University (Baltimore, Maryland, U.S.A.)

    "Quantitative proteomic studies of human inflammatory bowel disease"

    Abstract
    Maggio-Price, Lillian, V.M.D., Ph.D.
    University of Washington (Seattle, U.S.A.)

    "Helicobacter infection synergizes with impaired TGFb signaling to induce colon cancer in mice deficient in SMAD3"

    Abstract
    Mangino, Martin J., Ph.D.
    University of Wisconsin-Madison (U.S.A.)

    "Colonic lipoxin synthesis in patients and mice with inflammatory bowel disease"

    Presentation
    Mizoguchi, Emiko, M.D.
    Massachusetts General Hospital (Boston, U.S.A.)

    "Anti-inflammatory activity of the a-MSH and its tripeptide KPV in inflammatory bowel disease animal models"
    Morales, Victor M., Ph.D.
    Boston University Medical Center (Massachusetts, U.S.A.)

    "New methods for identification of peptides that stimulate T cells isolated from Crohn's disease subjects"

    Presentation
    Morrison, Douglas, Ph.D.
    University of Glasgow (Scotland)

    "Novel strategies for the colonic provision of butyric acid"
    Newberry, Rodney, M.D.
    Washington University (St. Louis, Missouri, U.S.A.)

    "Post-gestational lymphotoxin/ lymphotoxin beta receptor interactions essential to the intestinal immune response"
    Nuñez, Gabriel, M.D.
    University of Michigan Medical School (Ann Arbor, U.S.A.)

    "Nod2 is expressed in Paneth cells and regulates innate immunity to intracellular bacteria in the intestinal tract"

    Presentation
    Papadakis, Konstantinos A., M.D.
    Cedars-Sinai Medical Center (Los Angeles, California, U.S.A.)

    "Phenotypic and functional characterization of CCR9+ T lymphocytes in small intestinal Crohn's disease"

    Abstract
    Presentation
    Plevy, Scott E., M.D.
    University of Pittsburgh (Pennsylvania, U.S.A.)

    "Clostridium perfringens as a novel therapeutic vehicle in inflammatory bowel disease"

    Abstract
    Rampton, David S., BM, DPhil
    Queen Mary, University of London (United Kingdom)

    "Stress, hypnosis and ulcerative colitis"

    Abstract
    Presentation
    Rogler, Gerhard, M.D., Ph.D.
    University of Regensburg (Germany)

    "Role of NOD2/CARD15 for oxidative burst reaction and NF-kB activation in intestinal macrophages"

    Abstract
    Presentation
    Romagnuolo, Joseph, M.D.
    University of Calgary (Canada)

    "Wireless capsule endoscopy and intestinal permeability in asymptomatic first-degree relatives of Crohn's patients"

    Abstract
    Rottiers, Pieter, Ph.D.
    Ghent University (Belgium)

    "Treatment of experimental colitis by camelid antibody fragments: local administration and evaluation of their therapeutic potential"
    Rühl, Anne, M.D., Ph.D.
    Technical University of Munich (Germany)

    "Enteric glia in intestinal inflammation"

    Abstract
    Presentation
    Sano, Takeshi, Ph.D.
    Beth Israel Deaconess Medical Center (Boston, Massachusetts, U.S.A.)

    "Colon-directed delivery of viral vectors using virus-microbead conjugates for gene therapy of inflammatory bowel disease"

    Abstract
    Semret, Makeda M.D.
    McGill University (Montreal, Quebec, Canada)

    "Mycobacterium paratuberculosis in Crohn's: a study using tissue PCR, in situ PCR and gamma-interferon responses"

    Abstract
    Presentation
    Siegmund, Britta, M.D.
    Charité Universitätsmedizin Berlin, Campus Benjamin Franklin (Germany)

    "Specific inhibition of histone deacetylases as novel anti-inflammatory and anti-proliferative approach in experimental colitis"

    Abstract
    Smyrk, Thomas C., M.D.
    Mayo Clinic Rochester (Minnesota, U.S.A.)

    "HLA typing and expression: marker for identifying dysplasia and stratifying the risk for IBD-cancer"

    Abstract
    Presentation
    Söderholm, Johan D., M.D., Ph.D.
    Linköping University (Sweden)

    "Disrupted barrier to non-pathogenic E. coli in the follicle-associated epithelium of non-inflamed ileum of patients with Crohn's disease"

    Abstract
    Srikrishna, Geetha, Ph.D.
    The Burnham Institute (La Jolla, California, U.S.A.)

    "Understanding the role of carboxylated glycans, RAGE and S100 proteins in molecular events leading to pathogenesis of colitis"
    Stenson, William F., M.D.
    Washington University (St. Louis, Missouri, U.S.A.)

    "CTLA-4 immunoglobulin fusion protein increases indoleamine-2,3-dioxygenase expression and diminishes the severity of TNBS colitis"

    Abstract
    Swidsinski, Alexander, M.D., Ph.D.
    Charité Universitätsmedizin Berlin, Campus Charité-Mitte (Germany)

    "Spatial organization and composition of the mucosal flora in inflammatory bowel disease"

    Abstract
    Tannock, Gerald W., Ph.D.
    University of Otago (Dunedin, New Zealand)

    "Cloning the gut metagenome: a strategy to detect pro-inflammatory substances produced by intestinal bacteria"

    Abstract
    Van Kruiningen, Herbert J., DVM, Ph.D., M.D.
    University of Connecticut (Storrs, U.S.A.)

    "A PCR search for evidence of recurring or persistent viruses in Crohn's disease"

    Abstract
    Wittig, Bianca M., M.D.
    Charité Universitätsmedizin Berlin, Campus Benjamin Franklin (Germany)

    "Anti-CD44v7 antibody specifically induces the mitochondrial apoptosis pathway that is defective in Crohn's disease"

    Abstract
    Yacyshyn, Bruce R., M.D.
    Case Western Reserve University (Cleveland, Ohio, U.S.A.)

    "C-methyl cellulose reduces inflammatory measurements in the HLA-B27 transgenic rat model of inflammatory bowel diseases"

Last updated 04/01/2011