Fourth Annual BMRP Investigator Meeting

March 23-24, 2006
Los Angeles, California

(NOTE: You must have Adobe Reader software in order to open the presentation documents.)


    Invited Speakers:
    Shanahan, Fergus, M.D.
    Professor and Chairman, Department of Medicine; Director, Alimentary Pharmabiotic Centre, Biosciences Institute, University College Cork (United Kingdom)

    "Promises, promises - a perspective on IBD research directions"
    Scolnick, Edward, M.D.
    Director, Psychiatry Initiative, Broad Institute at MIT & Harvard; former President, Merck Research Laboratories

    "The route to drug discovery: a few examples"
    Presentation

    Scientific Summary of Meeting:
    Shanahan, Fergus, M.D.
    Professor and Chairman, Department of Medicine; Director, Alimentary Pharmabiotic Centre, Biosciences Institute University College Cork (United Kingdom)

    Presentations By BMRP Investigators:
    (partial list of talks and posters)
    Baumgart, Daniel C., M.D.
    Medical School of the Humboldt - University of Berlin (Germany)

    "Role of native human dendritic cells in inflammatory bowel disease"
    Behr, Marcel A., M.D.
    McGill University (Montreal, Quebec, Canada)

    "Detection of Mycobacterium avium paratuberculosis in Crohn's tissue"

    Abstract
    Bienenstock, John, M.D.
    McMaster University (Hamilton, Ontario, Canada)

    "The vagus nerve is involved in regulation of intestinal inflammation"
    Body-Malapel, Mathilde, Ph.D.
    University of Michigan (Ann Arbor, U.S.A.)

    "Role of Nod2 in the control of Paneth cell function and intestinal microflora"

    Abstract
    Braun, Jonathan, M.D., Ph.D.
    University of California, Los Angeles (U.S.A.)

    "Intestinal microbiota and systemic immune homeostasis"

    Abstract
    Büchner, Kerstin, M.D.
    Charitè-Universitätsmedizin Berlin, Campus Benjamin Franklin (Germany)

    "CD4+CD25+ T regulatory cells in inflammatory bowel disease"

    Abstract
    Clancy, Robert, M.D., Ph.D.
    University of Newcastle (Australia)

    "Mycobacterium avium ss paratuberculosis promotes but does not cause Crohn's disease"

    Abstract
    Danese, Silvio, M.D.
    Catholic University of Rome (Italy)

    "Angiogenesis as a novel component in the pathogenesis of inflammatory bowel disease"

    Abstract
    Denson, Lee A., M.D.
    Cincinnati Children's Hospital Medical Center (Ohio, U.S.A.)

    "STAT5b promotes mucosal tolerance in Crohn's disease and murine colitis"

    Presentation
    Ebert, Ellen C., M.D.
    University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School (New Brunswick, U.S.A.)

    "Sera from active ulcerative colitis contain IgG antibodies against human tropomyosin isoform 5(hTM5) that kills colonic epithelial cells through antibody and complement lysis"
    Föll, Dirk, M.D.
    University of Münster (Germany)

    "Neutrophil-derived S100A12 (EN-RAGE): Molecular basis of its expression, secretion, receptor-binding, and its role in inflammatory bowel disease"

    Abstract
    Gewirtz, Andrew, Ph.D.
    Emory University (Atlanta, Georgia, U.S.A.)

    "Humoral immune response to flagellin requires T-cells and activation of innate immunity"

    Presentation
    Greeley, George H., Jr., Ph.D.
    University of Texas at Galveston (U.S.A.)

    "Involvement of the apelin in colonic epithelial proliferation"

    Abstract
    Hoff, Sebastian
    Technical University of Munich (Germany)

    "Enteric glia in intestinal inflammation"

    Abstract
    Poster
    Kirkwood, Carl D., Ph.D.
    Murdoch Childrens Research Institute (Parkville, Australia)

    "Does a viral agent induce Crohn’s disease? A search for viral agents in children with early onset Crohn’s disease"

    Abstract
    Koide, Yukio, M.D., Ph.D.
    Hamamatsu University School of Medicine (Japan)

    "Curcumin maintenance therapy for ulcerative colitis: multicenter, double-blind, placebo-controlled, randomized clinical trial"

    Abstract
    Lamps, Laura W., M.D.
    University of Arkansas for Medical Sciences (Little Rock, U.S.A.)

    "Pathogenic Yersinia DNA detection in Crohn's disease"

    Abstract
    Leiter, Edward H., Ph.D.
    The Jackson Laboratory (Bar Harbor, Maine, U.S.A.)

    "Subcongenic analysis of Cdcs1, a major colitis susceptibility modifier in mice"

    Abstract
    Levitt, Michael, M.D.
    Minnesota Veterans Research Institute (Minneapolis, U.S.A.)

    "Possible role of hydrogen sulfide in the pathogenesis of pouchitis and ulcerative colitis"

    Presentation
    Li, Xuhang, Ph.D.
    Johns Hopkins University (Baltimore, Maryland, U.S.A.)

    "Proteomic study of inflammatory bowel disease"

    Presentation
    Maggio-Price, Lillian, V.M.D., Ph.D.
    University of Washington (Seattle, U.S.A.)

    "Absence of T and B cells in Smad3-KO mice with TGF-b dysregulation increases susceptibility to bacterial-induced inflammation and colon cancer"

    Abstract
    Mizoguchi, Atsushi, M.D., Ph.D.
    Massachusetts General Hospital (Boston, U.S.A.)

    "Therapeutic approach using interleukin-22 in experimental colitis"

    Abstract
    Morrison, Douglas, Ph.D.
    University of Glasgow (Scotland)

    "Novel strategies for the colonic provision of butyric acid"

    Abstract
    Muench, Marcus, Ph.D.
    Blood Systems Research Institute (San Francisco, California, U.S.A.)

    "Maternal microchimerism in inflammatory bowel disease"

    Abstract
    Papadakis, Konstantinos A., M.D.
    Cedars-Sinai Medical Center (Los Angeles, California, U.S.A.)

    "Phenotypic and functional characterization of CCR9+ T lymphocytes in small intestinal Crohn's disease"

    Abstract
    Pender, Sylvia L. F., Ph.D.
    University of Southampton (United Kingdom)

    "Role of macrophage metalloelastase (MMP-12) in inflammatory bowel disease"
    Plevy, Scott E., M.D.
    University of Pittsburgh (Pennsylvania, U.S.A.)

    "Clostridium perfringens as a novel therapeutic vehicle in inflammatory bowel disease"

    Abstract
    Presentation
    Rampton, David S., BM, DPhil
    Queen Mary, University of London (United Kingdom)

    "The effect of acute psychological stress on systemic and rectal mucosal measures of inflammation in ulcerative colitis"

    "The effect of hypnotherapy on systemic and rectal mucosal measures of inflammation in ulcerative colitis"

    Abstract #1
    Abstract #2
    Rosenberger, Carrie, Ph.D.
    Institute for Systems Biology (Seattle, Washington, U.S.A.)

    "Role of CREB transcription factors in regulating inflammatory responses"

    Abstract
    Sartor, R. Balfour, M.D.
    University of North Carolina at Chapel Hill (U.S.A.)

    "Cleavage products of kininogen variably induce pro-inflammatory cytokines by Fisher rat splenocytes"

    Abstract
    Srivastava, Anand, Ph.D.
    University of California, San Diego (La Jolla, U.S.A.)

    "Embryonic stem cells improve colitis and decrease IL-12 levels in the colitis mice"

    Abstract
    Török, Helga-Paula, M.D.
    Ludwig-Maximilians University (Munich, Germany)

    "NOD2/CARD15 mutations and apoptosis in Crohn's disease"

    Abstract
    Vandenbroucke, Klaas, Ph.D.
    Flanders Interuniversity Institute for Biotechnology (Zwijnaarde, Belgium)

    "Treatment of murine colitis by Lactococcus lactis secreting anti-tumor necrosis factor Nanobodies™"

    Abstract
    van der Zee, Ruurd, Ph.D.
    Utrecht University (The Netherlands)

    "Heat shock proteins as therapeutic agents for inflammatory bowel disease"

    Abstract
    Visser, Lydia, Ph.D.
    University of Groningen (The Netherlands)

    "Ex vivo treatment of biopsies in inflammatory bowel disease with galectin-1"
    Zasloff, Michael, M.D., Ph.D.
    Georgetown University (Washington, D.C., U.S.A.)

    "Rejection in the setting of small intestinal transplantation in man: a failure of intestinal innate immunity"

    Presentation

Last updated 04/01/2011