Eighth Annual BMRP Investigator Meeting

February 18-19, 2010
Los Angeles, California

(NOTE: You must have Adobe Acrobat software in order to open the presentation documents.)


    Invited Speakers:
    Bernstein, Charles N., M.D.
    Professor of Medicine and Bingham Chair in Gastroenterology Research, University of Manitoba (Winnipeg, Canada)

    "Environment and IBD: global lessons"

    Presentation

    Mazmanian, Sarkis K., Ph.D.
    Assistant Professor, Division of Biology, California Institute of Technology (Pasadena, U.S.A.)

    “Say hello to your little friends: symbiotic bacteria as novel therapies for IBD”

  

 

 


    Presentations By BMRP Investigators:
    (partial list of talks)
    Arancibia, Carolina, Ph.D.
    The University of Oxford (United Kingdom)

    "Characterization of dendritic cells in inflammatory bowel disease"
    Bentley, Robert, Ph.D.
    University of Otago (Christchurch, New Zealand)

    "Polymorphisms in innate immunity genes NOD2 and ATG16L1 affect the response of human monocytes to Mycobacterium avium subspecies paratuberculosis

    Abstract
     
    Presentation
    Bernstein, Charles N., M.D. 
    Professor of Medicine and Bingham Chair in Gastroenterology Research, University of Manitoba (Winnipeg, Canada)

    "A population-based characterization of potential microbial etiologies of IBD using geographically defined high and low rate prevalence/incidence areas in Manitoba"
    Cadwell, Ken, Ph.D.
    Washington University School of Medicine (St. Louis, Missouri, U.S.A.)

    "Interaction between a virus and the Crohn's disease gene ATG16L1"

    Abstract
     
    Presentation
    Caruso, Roberta, M.D.
    University Tor Vergata of Rome (Italy)

    "Antagonistic Effects of interleukin-25 on CD14+ cell cytokine responses in the gut"

    Abstract
     
    Presentation
    Cherayil, Bobby J., M.D.
    Harvard Medical School (Boston, Massachusetts, U.S.A.)

    "Manipulating iron metabolism to control intestinal inflammation"

    Abstract
     
    Presentation
    Creagh, Emma M., Ph.D.
    Trinity College (Dublin, Ireland)

    "Understanding the role and regulation of inflammasome-associated caspases in inflammatory bowel disease" 

    Croese, John, M.D.
    James Cooke University (Townsville, Australia)

    "Necator americanus (hookworm) modifies responses to gluten in celiac disease"
     
    Desseyn, Jean-Luc, Ph.D.
    University of Lille (France)

    "Protective action of a cysteine-rich mucin domain on the intestinal mucosa in experimental colitis"
    Dieleman, Levinus A., M.D., Ph.D.
    University of Alberta (Edmonton, Canada)

    "Capsule endoscopy for the assessment of abnormal intestinal permeability in Crohn's disease relatives" 

    Abstract
     
    Presentation
    Fayad, Raja A., M.D.
    University of South Carolina (Columbia, U.S.A.)

    "Adipose tissue macrophages: role in the development of strictures in Crohn's disease"
     
    Föll, Dirk, M.D., Ph.D.
    University of Münster (Germany)

    "GM-CSF induces monocyte subsets which ameliorate intestinal inflammation by specific immune activation" 
    Ganley-Leal, Lisa, Ph.D.
    Boston University School of Medicine (Massachusetts, U.S.A.)

    "Systemic toll-like receptor ligands modify B cell responses in chronic inflammatory disease patients"
    Hold, Georgina L., Ph.D. 
    University of Aberdeen (United Kingdom)

    "Assessment of non-pylori Helicobacter species in ulcerative colitis"
    Huang, Emina H., M.D.
    University of Florida (Gainesville, U.S.A.)

    "Colitis derived tumorigenic stem cells and the inflammatory bowel"

    Abstract

    Presentation
    Iebba, Valerio, Ph.D.
    Sapienza University of Rome (Italy)

    "Molecular characterization of mucosa-associated intestinal microbiota and intestinal innate immune response: searching for additional mechanisms in pediatric Crohn's disease"
    Knight, Stella C., Ph.D.
    Imperial College London (United Kingdom)

    "Leptin as an immunomodulatory target in Crohn's disease"
    Kuo, Calvin, M.D., Ph.D.
    Stanford University (California, U.S.A.)

    "In vitro culture approaches to intestinal stem cell biology and IBD"
    Laukens, Debby, Ph.D.
    Ghent University (Belgium)

    "Genetical genomics: A study of gene expression patterns in familial inflammatory bowel disease"

    Lindsay, James O., Ph.D.
    Barts and the London School of Medicine (United Kingdom)

    "Fructo-oligosaccharides in Crohn's disease:  a prospective randomized, double blind controlled trial with clinical immunological and microbiological endpoints"
    McLaughlin, Simon D., MBBS
    Imperial College London (United Kingdom)

    "The bacteriology of pouchitis: a molecular phylogenetic analysis using 16S rRNA gene cloning and sequencing"

    Abstract
     
    Presentation
    Mullin, James M., Ph.D.
    Lankenau Institute for Medical Research (Pennsylvania, U.S.A.)

    "Improvement of gastrointestinal barrier function and morbidity by restriction of sulfur-containing amino acids in Crohn's disease patients"

    Abstract

    Presentation
    Olsen, Ingrid, Ph.D.
    National Veterinary Institute (Oslo, Norway)

    "Isolation of Mycobacterium avium subspecies paratuberculosis antigen reactive T-lymphocytes from intestinal biopsies from Crohn's patients"

    Abstract

    Presentation
    Ott, Stephan J., M.D.
    University-Hospital Schleswig-Holstein (Germany)

    "The gut flora under environmental aspects: metagenomic alterations of the intestinal microbiome associated with lifestyle and their role in the pathogenesis of inflammatory bowel diseases"
     
    Abstract

    Presentation
    Petronis, Art, M.D., Ph.D.
    University of Toronto (Ontario, Canada)

    "Epigenomic studies of inflammatory bowel disease"
    Rayment, Neil, M.D.
    Kings College Hospital (London, United Kingdom)

    "The persistence of bacterial in lamina propria macrophages in Crohn's disease: role in pathogenesis"

 

    Rogler, Gerhard, M.D., Ph.D.
    University of Zurich (Switzerland)

    "Pathomechanisms of fistula formation in Crohn's disease patients" 

    Abstract

    Presentation
    Sitaraman, Shanthi, M.D., Ph.D.
    Emory University (Atlanta, Georgia, U.S.A.)

    "Treatment of experimental colitis using adenovirus-directed expression of prohibitin"
    Smith, Jill P., M.D.
    Pennsylvania State University (Hershey, U.S.A.)

    "Naltrexone therapy improves activity and promotes mucosal healing in active Crohn's disease: a placebo-controlled trial"
    Turner, Jerrold R., M.D., Ph.D.
    The University of Chicago (Illinois, U.S.A.)

    "Novel MLCK trafficking inhibitors correct TNF-induced tight junction barrier dysfunction"
    van Die, Irma, M.D., Ph.D.
    VU University Medical Center (Amsterdam, The Netherlands)

    "Worms to the rescue:  can worm glycans protect from inflammatory bowel disease?"
    Vogelaar, Lauran, Ph.D.
    Erasmus University (Rotterdam, The Netherlands)

    "Factors determining the severity of fatigue and the feasibility of fatigue management in Crohn's disease patients" 

    Abstract

    Presentation
    Wang, Weiwei, Ph.D.
    University of Alberta (Edmonton, Canada)

    "Viral triggers in inflammatory bowel disease" 

    Abstract

    Presentation