Grant Publications

Proposal No.  IBD-0007
Principal Investigator:  Johan D. Söderholm, M.D., Ph.D.
Applicant Organization:  Linköping University (Sweden)
Project Title:  The role of the follicle-associated epithelium in the initiation of inflammatory bowel disease 
Period of Award:  November 1, 2002 – September 30, 2005

Söderholm JD, Streuker C, Yang PC, Paterson C, Singh PK, McKay DM, Sherman PM, Croitoru K, Perdue MH.  Increased epithelial uptake of protein antigens in the ileum of Crohn's disease mediated by tumour necrosis factor alpha.  Gut 2004;53:1817-24.

Velin AK, Ericson AC, Braaf Y, Wallon C, Söderholm JD.  Increased antigen and bacterial uptake in follicle associated epithelium induced by chronic psychological stress in rats.  Gut 2004;53:494-500.

Wallon C, Braaf Y, Wolving M, Olaison G, Söderholm JD.  Endoscopic biopsies in Ussing chambers evaluated for studies of macromolecular permeability in the human colon.  Scandinavian Journal of Gastroenterology 2005;40:586-95.

Gullberg E, Keita AV, Salim SY, Andersson M, Caldwell KD, Söderholm JD, Artursson P.  Identification of cell adhesion molecules in the human follicle-associated epithelium that improve nanoparticle uptake into the Peyer's patches.  Journal of Pharmacology and Experimental Therapeutics 2006;319:632-9.

Gullberg E, Söderholm JD.  Peyer's patches and M cells as potential sites of the inflammatory onset in Crohn's disease.  Annals of the New York Academy of Sciences 2006;1072:218-32.

Keita AV, Gullberg E, Ericson AC, Salim SY, Wallon C, Kald A, Artursson P, Söderholm JD. Characterization of antigen and bacterial transport in the follicle-associated epithelium of human ileum. Laboratory Investigation 2006;86:504-16.

Keita AV, Salim SY, Jiang T, Yang PC, Franzén L, Söderkvist P, Magnusson KE, Söderholm JD.  Increased uptake of non-pathogenic E. coli via the follicle-associated epithelium in longstanding ileal Crohn's disease.  Journal of Pathology 2008;215:135-44.

Salim SY, Silva MA, Keita AV, Larsson M, Andersson P, Magnusson KE, Perdue MH, Söderholm JD.  CD83+CCR7- dendritic cells accumulate in the subepithelial dome and internalize translocated Escherichia coli HB101 in the Peyer's patches of ileal Crohn's disease.  American Journal of Pathology 2009;174:82-90.