Grant Publications

Proposal No.  IBD-0008
Principal Investigator:  Sander J. van Deventer, Ph.D., M.D.
Applicant Organization:  Academic Medical Centre Medical Research B.V. (Amsterdam, The Netherlands)
Project Title:  Treatment of Crohn's disease by Lactococcus lactis secreting human IL-10
Period of Award:  December 1, 2002 – November 30, 2003

Braat H, van den Brande J, van Tol E, Hommes D, Peppelenbosch, van Deventer S.  Lactobacillus rhamnosus induces peripheral hyporesponsiveness in stimulated CD4⁺ T cells via modulation of dendritic cell function.  American Journal of Clinical Nutrition 2004;80:1618-25.

Braat H, Stokker P, Hommes T, Cohn D, Vogels E, Pronk In, Spek A, van Kampen A, van Deventer S, Peppelenbosch, Hommes D.  Consequence of functional Nod2 and Tlr4 mutations on gene transcription in Crohn's disease patients.  Journal of Molecular Medicine 2005;83:601-9.

Braat H, Rottiers P, Hommes DW, Huyghebaert N, Remaut E, Remon JP, van Deventer SJ, Neirynck S, Peppelenbosch MP, Steidler L.  A phase I trial with transgenic bacteria expressing interleukin-10 in Crohn's disease.  Clinical Gastroenterology and Hepatology 2006;4:754-759.