Grant Publications

Proposal No.  IBD-0012R
Principal Investigator:  Lee A. Denson, M.D.
Current Applicant Organization:  Cincinnati Children's Hospital Medical Center (Ohio, U.S.A.)
Original Applicant Organization:  Yale University (New Haven, Connecticut, U.S.A.)
Project Title:  Mechanisms of growth hormone resistance in experimental colitis
Period of Award:  October 1, 2002 – March 31, 2006

DiFedele LM, He J, Bonkowski EL, Han X, Held MA, Bohan A, Menon RK, Denson LA.  Tumor necrosis factor alpha blockade restores growth hormone signaling in murine colitis.  Gastroenterology 2005;128:1278-91.

Han X, Sosnowska D, Bonkowski EL, Denson LA.  Growth hormone inhibits signal transducer and activator of transcription 3 activation and reduces disease activity in murine colitis.  Gastroenterology 2005;129:185-203.

Han X, Osuntokun B, Benight N, Loesch K, Frank S, Denson LA.  Signal transducer and activator of transcription 5b (STAT5b) promotes mucosal tolerance in pediatric Crohn's disease and murine colitis.  American Journal of Pathology 2006;169:1999-2013.

Dejkhamron P, Thimmarayappa J, Kotlyarevska K, Sun J, Lu C, Bonkowski EL, Denson LA, Menon RK.  Lipopolysaccharide (LPS) directly suppresses growth hormone receptor (GHR) expression through MyD88-dependent and -independent Toll-like receptor-4/MD2 complex signaling pathways.  Molecular and Cellular Endocrinology 2007;274:35-42.

Han X, Benight N, Osuntokun B, Loesch K, Frank SJ, Denson LA.  Tumor necrosis factor alpha blockade induces an anti-inflammatory growth hormone signaling pathway in experimental colitis.  Gut 2007;56:73-81.

Carey R, Jurickova I, Ballard E, Bonkowski E, Han X, Xu H, Denson LA.  Activation of an IL-6:STAT3-dependent transcriptome in pediatric-onset inflammatory  bowel disease.  Inflammatory Bowel Diseases 2008;14:446-57.

Wang X, Jiang J, Warram J, Baumann G, Gan Y, Menon RK, Denson LA, Zinn KR, Frank SJ.  Endotoxin-induced proteolytic reduction in hepatic growth hormone (GH) receptor: a novel mechanism for GH insensitivity.  Molecular Endocrinology 2008;22:1427-37.

Han X, Ren X, Jurickova I, Groschwitz K, Pasternak BA, Xu H, Wilson TA, Hogan SP, Denson LA.  Regulation of intestinal barrier function by signal transducer and activator of transcription 5b.  Gut 2009;58:49-58.