Grant Publications

Proposal No.  IBD-0020R
Principal Investigator:  Giovanni Monteleone, M.D., Ph.D.
Applicant Organization:  University Tor Vergata of Rome (Italy)
Project Title:  Role of Smad7, an inhibitor of TGF-beta1 signaling, in chronic intestinal inflammation
Period of Award:  September 1, 2002 - November 30, 2004

Monteleone G, Del Vecchio Blanco G, Palmieri G, Vavassori P, Monteleone I, Colantoni A, Battista S, Spagnoli LG, Romano M, Borrelli M, MacDonald TT, Pallone F.  Induction and regulation of Smad7 in the gastric mucosa of patients with Helicobacter pylori infection.  Gastroenterology 2004;126:674-82.

Monteleone G, Mann J, Monteleone I, Vavassori P, Brenner R, Fantini M, Del Vecchio Blanco G, Tersigni R, Alessandroni L, Mann D, Pallone F, MacDonald TT.  A failure of transforming growth factor-b 1 negative regulation maintains sustained NF-κB activation in gut inflammation.  Journal of Biological Chemistry 2004:279:3925-32.

Monteleone G, Pallone F, MacDonald TT.  Smad7 in TGF-beta-mediated negative regulation of gut inflammation.  Trends in Immunology 2004;25:513-7.

Monteleone G, Del Vecchio Blanco G, Monteleone I, Fina D, Caruso R, Gioia V, Ballerini S, Federici G, Bernardini S, Pallone F, MacDonald TT.  Post-transcriptional regulation of Smad7 in the gut of patients with inflammatory bowel disease.  Gastroenterology 2005;129:1420-9.

Monteleone G, Monteleone I, Fina D, Vavassori P, Del Vecchio Blanco G, Caruso R, Tersigni R, Alessandroni L, Biancone L, Naccari GC, Macdonald TT, Pallone F.  Interleukin-21 enhances T helper cell type I signalling and interferon-gamma production in Crohn's disease.  Gastroenterology 2005;128:687-94.

Boirivant M, Pallone F, Di Giacinto C, Fina D, Monteleone I, Marinaro M, Caruso R, Colantoni A, Palmieri G, Sanchez M, Strober W, Macdonald T, Monteleone G.  Inhibition of Smad7 with a specific antisense oligonucleotide facilitates TGF-beta1-mediated suppression of colitis.  Gastroenterology 2006;131:1786-98.