Grant Publications

Proposal No.  IBD-0021
Principal Investigator:  Hudson Freeze, Ph.D.
Applicant Organization:  The Burnham Institute (La Jolla, California, U.S.A.)
Project Title:  An anti-glycan antibody (mAbGB3.1) as a novel therapy for Crohn's disease and ulcerative colitis 
Period of Award:  August 1, 2002 - March 31, 2005

Srikrishna G, Turovskaya O, Shaikh R, Newlin R, Foell D, Murch S, Kronenberg M, Freeze HH.  Carboxylated glycans mediate colitis through activation of NF-κB.  The Journal of Immunology 2005;175:5412-22.

Sinha P, Okoro C, Foell D, Freeze H, Ostrand-Rosenberg S, Srikrishna G.  Proinflammatory proteins regulate the accumulation of myeloid derived suppressor cells.  Journal of Immunology 2008;181:4666-75.

Turovskaya O, Foell D, Sinha P, Vogl T, Robbin N, Nayak J, Nguyen M, Olsson A,  Nawroth PP, Bierhaus A, Varki N, Kronenberg M, Freeze HH, Srikrishna G.  RAGE, carboxylated glycans and S100A8/A9 play essential roles in colitis-associated carcinogenesis.  Carcinogenesis 2008;29:2035-43.

Srikrishna G, Freeze H.  Endogenous damage-associated molecular pattern (DAMP) molecules at the crossroads of inflammation and cancer.  Neoplasia 2009;11:615-28.