Grant Publications

Proposal No.  IBD-0024R
Principal Investigator:  Laura P. Hale, M.D., Ph.D.
Applicant Organization:  Duke University (Durham, North Carolina, U.S.A.)
Project Title:  Bromelain treatment of inflammatory bowel disease
Period of Award:  December 1, 2003 - February 28, 2005

Hale LP.  Proteolytic activity and immunogenecity of oral bromelain within the gastrointestinal tract of mice.  International Immunopharmacology 2004;4:255-64.

Hale LP, Gottfried MR, Swidsinski A.  Piroxicam treatment of IL-10 deficient mice enhances colonic epithelial apoptosis and mucosal exposure to intestinal bacteria.  Inflammatory Bowel Diseases 2005;11:1060-9.

Hale LP, Greer PK, Trinh CT, Gottfried MR.  Treatment with oral bromelain decreases colonic inflammation in the IL-10-deficient murine model of inflammatory bowel disease.  Clinical Immunology 2005;116:135-42.

Hale LP, Greer PK, Trinh CT, James CL.  Proteinase activity and stability of natural bromelain preparations.  International Immunopharmacology 2005;5:783-93.

Swidsinski A, Loening-Bauke V, Lochs H, Hale LP.  Spatial organization of bacterial flora in normal and inflamed intestine:  a fluorescence in situ hybridization study in mice.  World Journal of Gastroenterology 2005;11:1131-40.

Swidsinski A, Schlien P, Pernthaler A, Gottschalk U, Bärlehner E, Decker G, Swidsinski S, Strassburg J, Loening-Bauke V, Hoffmann U, Seehofer D, Hale LP, Lochs H.  Bacterial biofilm within diseased pancreatic and biliary tracts.  Gut 2005;54:388-95.

Swidsinski A, Weber J, Loening-Bauke V, Hale LP, Lochs H.  Spatial organization and composition of the mucosal flora in patients with inflammatory bowel disease.  Journal of Clinical Microbiology 2005;43:3380-9.

Hale L, Perera D, Gottfried MR, Maggio-Price L, Srinivasan S, Marchuk D.  Neonatal co-infection with Helicobacter species markedly accelerates the development of inflammation-associated colonic neoplasia in IL-10-/- mice.  Helicobacter 2007;12:598-604.

Onken JE, Greer PK, Calingaert B, Hale LP.  Bromelain treatment decreases secretion of pro-inflammatory cytokines and chemokines by colon biopsies in vitro.  Clinical Immunology 2008;126:345-52.