Grants Funded in 2003

Principal Investigator:  Baumgart, Daniel C., M.D., Ph.D.
Proposal No. IBD-0067R
Applicant Organization:  Charité Medical Center - Medical School of the Humboldt - University of Berlin (Germany)
Project Title:  Dendritic cells in inflammatory bowel disease
Period of Award:  September 1, 2003 - March 31, 2006
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Principal Investigator:  Behr, Marcel A., M.D.
Proposal No. IBD-0074R
Applicant Organization:  McGill University Health Centre Research Institute (Canada)
Project Title:  Molecular and immunologic detection of Mycobacterium avium paratuberculosis in Crohn's disease
Period of Award:  December 1, 2003 - March 31, 2006
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Principal Investigator:  Blumberg, Richard, M.D.
Proposal No. NICE-07
Applicant Organization:  Brigham and Women's Hospital (U.S.A.)
Project Title:  Functionally characterize modulins which bind to and regulate intestinal epithelial cell function
Period of Award:  January 1, 2003 - December 31, 2003
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Principal Investigator:  Bond, Judith, Ph.D. (replacement PI);  Crisman, Jacqueline, Ph.D. (original PI)
Proposal No. IBD-0066
Applicant Organization:  The Pennsylvania State University College of Medicine (U.S.A.)
Project Title:  Intestinal leukocyte infiltration is mediated by meprin beta
Period of Award:  June 1, 2003 - July 31, 2004
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Principal Investigator:  Cartwright, Christine, M.D.
Proposal No. IBD-0068R
Applicant Organization:  Stanford University (U.S.A.)
Project Title:  Ulcerative colitis: molecular mechanisms of carcinogenesis
Period of Award:  September 1, 2003 - March 31, 2006
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Principal Investigator:  Chakravarti, Shukti, Ph.D.
Proposal No. IBD-0051R2
Applicant Organization:  Johns Hopkins University (U.S.A.)
Project Title: Molecular classification of Crohn's disease subtypes by gene expression profiling
Period of Award:  July 1, 2003 - February 28, 2005
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Principal Investigator:  Cominelli, Fabio, M.D., Ph.D.
Proposal No. NICE-06
Applicant Organization:  University of Virginia (U.S.A.)
Project Title:  Establishment of mouse T cell lines that respond to bacterial antigens
Period of Award:  January 1, 2003 - December 31, 2003
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Principal Investigator:  Elson, Charles, M.D.
Proposal No. NICE-01
Applicant Organization:  University of Alabama at Birmingham (U.S.A.)
Project Title: Establish mouse T-cell lines that respond to novel bacterial antigens
Period of Award:  January 1, 2003 - December 31, 2005
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Principal Investigator:  Esworthy, Robert Steven, Ph.D.
Proposal No. IBD-0050
Applicant Organization:  City of Hope National Medical Center (U.S.A.)
Project Title:  Barrier breakdown in mice deficient in antioxidant defenses leads to ileal colitis
Period of Award:  February 1, 2003 - May 31, 2004
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Principal Investigator:  Föll, Dirk, M.D.
Proposal No. IBD-0076
Applicant Organization:  University Hospital of Muenster (Germany)
Project Title:  The role of the receptor for advanced glycation end products (RAGE) and its ligand S100A12 (EN-RAGE) in chronic inflammatory bowel disease
Period of Award:  November 1, 2003 - June 30, 2006
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Principal Investigator:  Ghosh, Subrata, M.D.
Proposal No. IBD-0040R
Applicant Organization:  Imperial College School of Science, Technology and Medicine (United Kingdom)
Project Title:  Do dietary microparticles modulate macrophage activation and phagocytosis in Crohn's disease?
Period of Award:  September 1, 2003 - April 30, 2005
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Principal Investigator:  Hebert, Steven C., M.D.
Proposal No. IBD-0047R
Applicant Organization:  Yale University (U.S.A.)
Project Title:  The colonic epithelial extracellular calcium(nutrient)-sensing receptor as a modulator of inflammatory bowel disease
Period of Award:  March 1, 2003 - August 31, 2005
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Principal Investigator:  Holcombe, Randall F., M.D.
Proposal No. IBD-0065R
Applicant Organization:  University of California, Irvine (U.S.A.)
Project Title:  Wnt signaling in inflammatory bowel disease-related colon cancer
Period of Award:  November 1, 2003 - October 31, 2005
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Principal Investigator:  Jewell, Derek P., BM, BCh, DPhil
Proposal No. IBD-0055
Applicant Organization:  University of Oxford (United Kingdom)
Project Title:  Identification of the susceptibility gene for colonic Crohn's disease by targeted positional cloning and microarray expression studies
Period of Award:  March 1, 2003 - February 29, 2004
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Principal Investigator:  Kim, Chang H., Ph.D.
Proposal No. IBD-0053
Applicant Organization:  Purdue University (U.S.A.)
Project Title:  CXCL16 and CXCR6 in Crohn’s disease
Period of Award:  February 1, 2003 - January 31, 2004
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Principal Investigator:  Kobayashi, Koichi, M.D., Ph.D.
Proposal No. IBD-0052
Applicant Organization:  Yale University (U.S.A.)
Project Title:  A role of innate immunity in the pathogenesis of inflammatory bowel disease
Period of Award:  January 1, 2003 - February 28, 2005
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Principal Investigator:  Krissansen, Geoffrey W., Ph.D.
Proposal No. IBD-0003R
Applicant Organization:  University of Auckland (New Zealand)
Project Title:  Pattern recognition receptors as potential susceptibility loci for Crohn's disease
Period of Award:  November 1, 2002 - March 31, 2005      
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Principal Investigator:  Kucharzik, Torsten, M.D.
Proposal No. IBD-0038
Applicant Organization:  University of Münster (Germany)
Project Title:  Role of alpha-MSH and related tripeptides as potential anti-inflammatory agents during inflammatory bowel disease
Period of Award:  January 1, 2003 - December 31, 2004
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Principal Investigator:  Mahmood, Umar, M.D., Ph.D.
Proposal No. IBD-0043
Applicant Organization:  Massachusetts General Hospital (U.S.A.)
Project Title:  Optical imaging of protease activity for early detection of adenomas/ adenocarcinomas in colitis
Period of Award:  March 1, 2003 - May 31, 2004
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Principal Investigator:  Mayer, Lloyd, M.D.
Proposal No. NICE-04
Applicant Organization:  Mount Sinai School of Medicine (U.S.A.)
Project Title:  Define bacterial antigens affecting epithelial cell phenotype and function
Period of Award:  January 1, 2003 - December 31, 2003
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Principal Investigator:  Mizoguchi, Emiko, M.D., Ph.D.
Proposal No. IBD-0048
Applicant Organization:  Massachusetts General Hospital (U.S.A.)
Project Title:  Role of tumor necrosis factor receptors of colonic epithelial cells in inflammatory bowel disease
Period of Award:  March 1, 2003 - May 31, 2005
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Principal Investigator:  Morrison, Douglas, Ph.D.
Proposal No. IBD-0023
Applicant Organization:  University of Glasgow (United Kingdom)
Project Title:  Novel strategies for the colonic provision of butyric acid
Period of Award:  June 1, 2003 - March 31, 2006
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Principal Investigator:  Newberry, Rodney, M.D.
Proposal No. IBD-0042
Applicant Organization:  Washington University (U.S.A.)
Project Title:  Post-gestational lymphotoxin/lymphotoxin beta receptor interactions essential to the intestinal immune response
Period of Award:  January 1, 2003 - March 31, 2005
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Principal Investigator:  Podolsky, Daniel, M.D.
Proposal No. NICE-05
Applicant Organization:  Massachusetts General Hospital (U.S.A.)
Project Title:  Define human T cell and antibody responses to dominant intestinal antigens
Period of Award:  January 1, 2003 - December 31, 2003
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Principal Investigator:  Rampton, David S., BM, DPhil
Proposal No. IBD-0031R
Applicant Organization:  Queen Mary, University of London (United Kingdom)
Project Title:  Stress and hypnosis in ulcerative colitis
Period of Award:  August 1, 2003 - July 31, 2005
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Principal Investigator:  Rogler, Gerhard, M.D., Ph.D.
Proposal No. IBD-0045R
Applicant Organization:  University of Regensburg (Germany)
Project Title:  Role of CARD15/NOD2 for oxidative burst reaction and NF-kappaB activation in intestinal macrophages
Period of Award:  October 1, 2003 - February 28, 2006
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Principal Investigator:  Romagnuolo, Joseph, M.D.
Proposal No. IBD-0063
Current Applicant Organization:  Medical University of South Carolina (U.S.A.)
Original Applicant Organization:  University of Calgary (Canada)
Project Title:  Capsule endoscopic findings and incidence of disease in first-degree relatives of Crohn's patients with abnormal intestinal permeability
Period of Award:  October 1, 2003 - September 30, 2006
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Principal Investigator:  Sano, Takeshi, Ph.D.
Proposal No. IBD-0078
Applicant Organization:  Beth Israel Deaconess Medical Center (U.S.A.)
Project Title:  A colon-directed gene transfer technology for gene therapy of inflammatory bowel disease
Period of Award:  November 1, 2003 - October 31, 2005
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Principal Investigator:  Sartor, R. Balfour, M.D.
Proposal No. NICE-03
Applicant Organization:  University of North Carolina at Chapel Hill (U.S.A.)
Project Title:  Identification of dominant bacterial antigens from IL-10 knockout mice and HLA-527 transgenic rats with colitis
Period of Award:  January 1, 2003 - December 31, 2004
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Principal Investigator:  Stadnyk, Andrew W., Ph.D.
Proposal No. IBD-0056
Applicant Organization:  Dalhousie University (Canada)
Project Title:  Targeting neutrophil transepithelial migration as a means of controlling inflammation
Period of Award:  June 1, 2003 - May 31, 2004
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Principal Investigator:  Stenson, William, M.D.
Proposal No. IBD-0070R
Applicant Organization:  Washington University (U.S.A.)
Project Title:  Indoleamine 2,3-dioxygenase in inflammatory bowel disease
Period of Award:  October 1, 2003 - September 30, 2005
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Principal Investigator:  Swidsinski, Alexander, M.D., Ph.D.
Proposal No. IBD-0030
Applicant Organization:  The University Hospital Charité of the Humboldt University at Berlin (Germany)
Project Title:  In situ characterization of the mucosal bacterial biofilm in patients with inflammatory bowel disease using universal and group/species specific FISH probes
Period of Award:  January 1, 2003 - March 31, 2005
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Principal Investigator:  Tannock, Gerald, Ph.D.
Proposal No. IBD-0073
Applicant Organization:  University of Otago (New Zealand)
Project Title:  Cloning the gut metagenome: a strategy to detect pro-inflammatory substances produced by intestinal bacteria
Period of Award:  September 1, 2003 - December 31, 2006
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Principal Investigator:  Targan, Stephan, M.D.
Proposal No. NICE-02
Applicant Organization:  Cedars-Sinai Medical Center (U.S.A.)
Project Title:  Define human T cell and antibody responses to dominant intestinal antigens
Period of Award:  January 1, 2003 - December 31, 2004
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Principal Investigator:  Wittig, Bianca Maria, M.D.
Proposal No. IBD-0079
Applicant Organization:  University Hospital Benjamin Franklin, Free University Berlin (Germany)
Project Title:  Modulation of CD44: a new therapeutic approach in inflammatory bowel disease?
Period of Award:  December 1, 2003 - May 31, 2006
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Principal Investigator:  Yacyshyn, Bruce R., M.D.
Proposal No. IBD-0061
Applicant Organization:  Case Western Reserve University (U.S.A.)
Project Title:  Exposure to bacterial flora and gut permeability: a mechanistic correlation in the HLA-B27 animal model of inflammatory bowel disease
Period of Award:  July 1, 2003 - June 30, 2005
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