Scientific Abstract

Proposal No.  NICE-07
Principal Investigator:  Richard Blumberg, M.D.
Applicant Organization:  Brigham and Women's Hospital (Boston, Massachusetts, U.S.A.)
Project Title:  Functionally characterize modulins which bind to and regulate intestinal epithelial cell function
Period of Award:  January 1, 2003 - December 31, 2003

Specific Aims

   1.    Identify modulins that regulate epithelial cell function, especially with regard to those that regulate proinflammatory cytokine secretion, anti-inflammatory cytokine secretion and epithelial cell barrier function.
   2.    Establish in vivo effects of modulins in ameliorating colitis associated with inflammatory bowel disease in animal models of colitis.