Grant Publications

Proposal No. IBD-0030
Principal Investigator:  Alexander Swidsinski, M.D., Ph.D.
Applicant Organization:  The University Hospital Charité of the Humboldt University at Berlin (Germany)
Project Title:  In situ characterization of the mucosal bacterial biofilm in patients with inflammatory bowel disease using universal and group/species specific FISH probes
Period of Award:  January 1, 2003 – March 31, 2005

Hale LP, Gottfried MR, Swidsinski A.  Piroxicam treatment of IL-10 deficient mice enhances colonic epithelial apoptosis and mucosal exposure to intestinal bacteria.  Inflammatory Bowel Diseases 2005;11:1060-9.

Swidsinski A, Loening-Bauke V, Lochs H, Hale LP.  Spatial organization of bacterial flora in normal and inflamed intestine:  a fluorescence in situ hybridization study in mice.  World Journal of Gastroenterology 2005;11:1131-40.

Swidsinski A, Schlien P, Pernthaler A, Gottschalk U, Bärlehner E, Decker G, Swidsinski S, Strassburg J, Loening-Bauke V, Hoffmann U, Seehofer D, Hale LP, Lochs H.  Bacterial biofilm within diseased pancreatic and biliary tracts.  Gut 2005;54:388-95.

Swidsinski A, Weber J, Loening-Bauke V, Hale LP, Lochs H.  Spatial organization and composition of the mucosal flora in patients with inflammatory bowel disease.  Journal of Clinical Microbiology 2005;43:3380-9.

Swidsinski A, Loening-Bauck V, Bengmark S, Lochs H, Doerffel Y.  Azathioprine and mesalazine-induced effects on the mucosal flora in patients with IBD colitis.  Inflammatory Bowel Diseases 2007;13:51-6.

Swidsinski A, Sydora BC, Coerffel Y, Loening-Baucke V, Vaneechoutte M, Lupicki M, Scholze J, Lochs H, Dieleman LA.  Viscosity gradient within the mucus layer determines the mucosal barrier function and the spatial organization of the intestinal microbiota.  Inflammatory Bowel Diseases 2007;13:963-70.