Grant Publications

Proposal No.   IBD-0038
Principal Investigator:  Torsten Kucharzik, M.D.
Applicant Organization:  University of Münster (Germany)
Project Title: Role of alpha-MSH and related tripeptides as potential anti-inflammatory agents during inflammatory bowel disease
Period of Award:  January 1, 2003 – December 31, 2004

Maaser C, Kannengiesser K, Kucharzik T.  Role of the melanocortin system in inflammation.  Annals of the New York Academy of Sciences 2006;1072:123-34.

Maaser C, Kannengiesser K, Specht C, Luegering A, Brzoska T, Luger TA, Domschke W, Kucharzik T.  Crucial role of the melanocortin receptor MC1R in experimental colitis.  Gut 2006;55:1415-22.

Brzoska T, Luger TA, Maaser C, Abels C, Bohm M.  Alpha-melanocyte-stimulating hormone and related tripeptides: biochemistry, antiinflammatory and protective effects in vitro and in vivo, and future perspectives for the treatment of immune-mediated inflammatory diseases.  Endocrine Reviews 2008;29:581-602.

Kannengiesser K, Maaser C, Heidemann J, Lugering A, Brzoska T, Luger TA, Domschke W, Kucharzik T.  Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease.  Inflammatory Bowel Diseases 2008;14:324-31.

Bettenworth D, Buyse M, Böhm M, Mennigen R, Czorniak I, Kannengiesser K, Brzoska T, Luger TA, Kucharzik T, Domschke W, Maaser C, Lügering A.  The tripeptide KdPT protects from intestinal inflammation and maintains intestinal barrier function.  American Journal of Pathology 2011;179:1230-42.