Grant Publications

Proposal No.   IBD-0045R
Principal Investigator:  Gerhard Rogler, M.D., Ph.D.
Applicant Organization: University of Regensburg (Germany)
Project Title: Role of CARD15/NOD2 for oxidative burst reaction and NF-kappaB activation in intestinal macrophages
Period of Award:  October 1, 2003 - February 28, 2006

Holler E, Rogler G, Herfarth H, Brenmoehl J, Wild PJ, Hahn J, Eissner G, Scholmerich J, Andreesen R.  Both donor and recipient NOD2/CARD15 mutations associate with transplant-related mortality and GvHD following allogeneic stem cell transplantation.  Blood 2004;104:889-94.

Rogler G, Holler E.  Can NOD2/CARD15 mutations predict intestinal graft-versus-host disease and aid our understanding of Crohn's disease?  Nature Clinical Practice Gastroenterology and Hepatology 2004;1:62-3.

Holler E, Rogler G, Brenmoehl J, Hahn J, Herfarth H, Greinix H, Dickinson AM, Socie G, et al.  Prognostic significance of NOD2/CARD15 variants in HLA-identical sibling hematopoietic stem cell transplantation: effect on long-term outcome is confirmed in 2 independent cohorts and may be modulated by the type of gastrointestinal decontamination.  Blood 2006;107:4189-93.

Brenmoehl J, Herfarth H, Glück T, Audebert F, Barlage S, Schmitz G, Froehlich D, Schreiber S, Hampe J, Schölmerich J, Holler E, Rogler G.  Genetic variants in the NOD2/CARD15 gene are associated with early mortality in sepsis patients.  Intensive Care Medicine 2007;33:1541-8.

Kosovac K, Brenmoehl J, Holler E, Falk W, Schoelmerich J, Hausmann M, Rogler G.  Association of the NOD2 genotype with bacterial translocation via altered cell-cell contacts in Crohn's disease patients.  Inflammatory Bowel Diseases 2010;16:1311-21.