Grant Publications
Proposal No. IBD-0048
Principal Investigator: Emiko Mizoguchi, M.D., Ph.D.
Applicant Organization: Massachusetts General Hospital (Boston, U.S.A.)
Project Title: Role of tumor necrosis factor receptors of colonic epithelial cells in inflammatory bowel disease
Period of Award: March 1, 2003 - May 31, 2005
Brodeur SR, Angelini F, Bacharier LB, Blom AM, Mizoguchi E, Fujiwara H, Plebani A, Notarangelo LD, Dahlback B, Tsitsikov E, Geha RS. C4b-binding protein (C4BP) activates B cells through the CD40 receptor. Immunity 2003;18:837-48.
Colgan SP, Pitman RS, Nagaishi T, Mizoguchi A, Mizoguchi E, Mayer LF, Shao L, Sartor RB, Subjeck JR, Blumberg RS. Intestinal heat shock protein 110 regulates expression of CD1d on intestinal epithelial cells. Journal of Clinical Investigation 2003;112:745-54.
Mizoguchi E, Xavier RJ, Reinecker H-C, Uchino H, Bhan AK, Podolsky DK, Mizoguchi A. Colonic epithelial functional phenotype varies with type and phase of experimental colitis. Gastroenterology 2003;125:148-61.
Hokama A, Mizoguchi E, Sugimoto K, Shimomura Y, Tanaka Y, Yoshida M, Rietdijk ST, de Jong YP, Snapper SB, Terhorst C, Blumberg RS, Mizoguchi A. Induced reactivity of intestinal CD4+ T cells with an epithelial cell lectin, galectin-4, contributes to exacerbation of intestinal inflammation. Immunity 2004;20-681-93.
Mizoguchi E. Chitinase-3-like-1 exacerbates intestinal inflammation by enhancing bacterial adhesion and invasion in colonic epithelial cells. Gastroenterology 2006;130:398-411.
Kawada M, Arihiro A, Mizoguchi E. Insights from advances in research of chemically induced experimental models of human inflammatory bowel disease. World Journal of Gastroenterology 2007;13:3671-76.
Kawada M, Hachiya Y, Arihiro A, Mizoguchi E. Role of mammalian chitinases in inflammatory conditions. Keio Journal of Medicine 2007;56:21-7.
Mizoguchi E, Mizoguchi A. Is the sugar always sweet in intestinal inflammation? Immunologic Research 2007;37:47-60.
Kawada M, Chen CC, Arihiro A, Nagatani K, Watanbe T, Mizoguchi E. Chitinase 3-like-1 enhances bacterial adhesion of colonic epithelial cells through the interaction with bacterial chitin-binding protein. Laboratory Investigation 2008;88:883-95.
Mizoguchi A, Mizoguchi E. Inflammatory bowel disease, past, present and future, lesson from animal models. Journal of Gastroenterology 2008;43:1-17.
Mizoguchi E, Hachiya Y, Kawada M, Nagatani K, Ogawa A, Sugimoto K, Mizoguchi A, Podolsky DK. TNF receptor type I-dependent activation of iinnate responses to reduce intestinal damage-associated mortality. Gastroenterology 2008;134:470-80.
Shimomura Y, Mizoguchi E, Sugimoto K, Kibe R, Benno Y, Mizoguchi A, Bhan AK. Regulatory role of B-1 B cells in chronic colitis. International Immunology 2008;20:729-37.
Shimomura Y, Ogawa A, Kawada M, Sugimoto K, Mizoguchi E, Shi HN, Pillai S, Bhan AK, Mizoguchi A. A unique B2 B cell subset in the intestine. Journal of Experimental Medicine 2008;205:1343-55.
Eurich K, Segawa M, Toei-Shimizu S, Mizoguchi E. Potential role of chitinase 3-like-1 in inflammation-associated carcinogenic changes of epithelial cells. World Journal of Gastroenterology 2009;15:5249-59.