Grant Publications

Proposal No. IBD-0050
Principal Investigator:  Robert Steven Esworthy, Ph.D.
Applicant Organization:  City of Hope National Medical Center (Duarte, California, U.S.A.)
Project Title:  Barrier breakdown in mice deficient in antioxidant defenses leads to ileal colitis
Period of Award:  February 1, 2003 - May 31, 2004

Chu FF, Esworthy RS, Chu PG, Longmate JA, Huycke MM, Wilczynski S, Doroshow JH.  Bacteria-induced intestinal cancer in mice with disrupted Gpx1 and Gpx2 genes.  Cancer Research 2004;64:962-8.

Chu FF, Esworthy RS, Doroshow JH.  Role of Se-dependent glutathoine peroxidases in gastrointestinal inflammation and cancer.  Free Radical Biology & Medicine 2004;36:1481-95.

Esworthy RS, Yang L, Frankel PH, Chu FF.  Epithelium-specific glutathione peroxidase, Gpx2, is involved in the prevention of intestinal inflammation in selenium-deficient mice.  The Journal of Nutrition 2005;135:740-5.

Lee DH, Esworthy RS, Chu C, Pfeifer GP, Chu FF.  Mutation accumulation in the intestine and colon of mice deficient in two intracellular glutathione peroxidases.  Cancer Research 2006;66:9845-51.