Grants Funded in 2004
Principal Investigator: Anderson, James, M.D., Ph.D.
Proposal No. IBD-0098
Applicant Organization: University of North Carolina at Chapel Hill (U.S.A.)
Project Title: The role of intestinal flora in transcriptional and functional control of the tight junction barrier
Period of Award: January 1, 2004 – February 28, 2005
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Principal Investigator: Bienenstock, John, M.D.
Proposal No. IBD-0109R
Applicant Organization: McMaster University (Canada)
Project Title: Is there a neurophysiologic basis for immunoregulation by probiotics?
Period of Award: September 1, 2004 – August 31, 2007
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Principal Investigator: Braun, Jonathan, M.D., Ph.D.
Proposal No. IBD-0093R2
Applicant Organization: University of California, Los Angeles (U.S.A.)
Project Title: The intestinal fungi: role in microbial consortia and mucosal immune homeostasis
Period of Award: October 1, 2004 – March 31, 2006
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Principal Investigator: Carrier, Ewa, M.D.
Proposal No. IBD-0114
Applicant Organization: University of California, San Diego (U.S.A.)
Project Title: Repair of Crohn’s disease with stem cells
Period of Award: September 1, 2004 – September 30, 2007
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Principal Investigator: Cho, Judy, M.D.
Proposal No. IBD-0133R
Applicant Organization: The University of Chicago (U.S.A.)
Project Title: Identification of inflammatory bowel disease susceptibility gene(s) on chromosome 3q
Period of Award: December 1, 2004 – May 31, 2006
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Principal Investigator: Clancy, Robert L., M.D., Ph.D.
Proposal No. IBD-0115
Applicant Organization: The University of Newcastle Research Associates (TUNRA) Limited (Australia)
Project Title: Mycobacterium avium paratuberculosis (MAP) plays a critical role in the pathogenesis of Crohn’s disease in a substantial proportion of subjects
Period of Award: April 19, 2004 – April 30, 2006
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Principal Investigator: Colman, Robert W., M.D.
Proposal No. IBD-0080R
Applicant Organization: Temple University (U.S.A.)
Project Title: Kallikrein-kinin system in inflammatory bowel disease
Period of Award: January 1, 2004 - December 31, 2006
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Principal Investigator: Gewirtz, Andrew T., Ph.D.
Proposal No. IBD-0102
Applicant Organization: Emory University (U.S.A.)
Project Title: Adaptive immunity to flagellin in inflammatory bowel disease
Period of Award: May 1, 2004 – April 30, 2006
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Principal Investigator: Greeley, George H., Jr., Ph.D.
Proposal No. IBD-0118
Applicant Organization: The University of Texas Medical Branch (U.S.A.)
Project Title: Protective and repair action of apelin, a new enteric protein, on the intestinal mucosa in experimental colitis
Period of Award: June 1, 2004 – September 30, 2006
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Principal Investigator: Hanski, Christoph, Ph.D.
Proposal No. IBD-0099R
Applicant Organization: Charité Universitätsmedizin Berlin, Campus Benjamin Franklin (Germany)
Project Title: Effects of deoxycholic acid and ursodeoxycholic acid on the development of carcinomas during chronic ulcerative colitis: proof of principle in an animal model
Period of Award: March 1, 2004 – June 30, 2006
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Principal Investigator: Hershberg, Robert, M.D., Ph.D.
Proposal No. NICE-08
Applicant Institution: University of Washington (U.S.A.)
Project Title: Therapeutic modulation of flagellin responses in inflammatory bowel disease
Award Period: January 1, 2004 - June 30, 2006
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Principal Investigator: Jobin, Christian, Ph.D.
Proposal No. IBD-0116R
Applicant Organization: University of North Carolina at Chapel Hill (U.S.A.)
Project Title: Modulation of innate signal transduction and experimental colitis by natural plant extracts
Period of Award: July 1, 2004 - December 31, 2005
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Principal Investigator: Koide, Yukio, M.D., Ph.D.
Proposal No. IBD-0069R2
Applicant Organization: Hamamatsu University (Japan)
Project Title: A randomized clinical trial of curcumin in the therapy of ulcerative colitis
Period of Award: January 1, 2004 - September 30, 2006
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Principal Investigator: Kwon, John H., M.D., (replacement PI);
Ginsburg, Philip M., M.D. (original PI)
Proposal No. IBD-0122R
Applicant Organization: Johns Hopkins University (U.S.A.)
Project Title: Differentiating fibrostenosing from inflammatory small bowel disease in patients with Crohn’s disease using combined 18F-fluorodeoxyglucose positron emission tomography and computed tomography
Period of Award: September 1, 2004 – December 31, 2005
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Principal Investigator: Lamps, Laura W., M.D.
Proposal No. IBD-0095
Applicant Institution: University of Arkansas for Medical Sciences (U.S.A.)
Project Title: Pathogenic Yersinia DNA detection in Crohn's disease
Award Period: January 1, 2004 - March 31, 2006
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Principal Investigator: Leiter, Edward, Ph.D.
Proposal No. IBD-0104
Applicant Organization: The Jackson Laboratory (U.S.A.)
Project Title: Functional genomics of colitis susceptibility in IL-10 deficient mice
Period of Award: March 1, 2004 – June 30, 2006
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Principal Investigator: Levi, Ben-Zion, Ph.D.
Proposal No. IBD-0125P
Applicant Organization: Technion - Israel Institute of Technology (Israel)
Project Title: Association between Nramp1 polymorphisms and Crohn’s disease in Israeli Jewish population
Period of Award: August 1, 2004 – July 31, 2005
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Principal Investigator: Maggio-Price, Lillian, V.M.D., Ph.D.
Proposal No. IBD-0106
Applicant Organization: University of Washington (U.S.A.)
Project Title: Molecular mechanism of colon carcinogenesis: collaborative effects of Helicobacter infection and TGF-β dysregulation
Period of Award: May 1, 2004 – November 30, 2006
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Principal Investigator: Mangino, Martin J., Ph.D.
Proposal No. IBD-0081R
Applicant Organization: University of Wisconsin-Madison (U.S.A.)
Project Title: Lipoxin metabolism in inflammatory bowel disease
Period of Award: February 1, 2004 - April 30, 2006
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Principal Investigator: Michel, Klaus, Ph.D. (replacement PI);
Rühl, Anne, M.D., Ph.D. (original PI)
Proposal No. IBD-0105R
Applicant Organization: Technische Universität München (Germany)
Project Title: Enteric glia in intestinal inflammation
Period of Award: July 1, 2004 – June 30, 2006
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Principal Investigator: Morales, Victor M., Ph.D.
Proposal No. IBD-0094
Applicant Organization: University of Rochester (replacement organization - U.S.A.)
Boston University Medical Center (original organization - U.S.A.)
Project Title: Peptides recognized by T cell clones from inflammatory bowel disease patients
Period of Award: February 1, 2004 - September 30, 2006
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Principal Investigator: Nuñez, Gabriel, M.D.
Proposal No. IBD-0091R
Applicant Organization: University of Michigan (U.S.A.)
Project Title: Role of Nod2 in the control of Paneth cell function and intestinal microflora
Award Period: May 1, 2004 - May 31, 2006
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Principal Investigator: Ortner, Maria-Anna, M.D.
Proposal No. IBD-0088
Applicant Organization: Centre Hospitalier Universitaire Vaudois (Switzerland)
Project Title: Photodynamic therapy in Crohn’s disease
Period of Award: February 1, 2004 - June 30, 2006
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Principal Investigator: Papadakis, Konstantinos, M.D.
Proposal No. IBD-0092R
Applicant Organization: Cedars-Sinai Medical Center (U.S.A.)
Project Title: Phenotypic and functional characterization of CCR9+ T lymphocytes in small intestinal Crohn’s disease
Period of Award: April 1, 2004 – December 31, 2005
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Principal Investigator: Pender, Sylvia Lin Foon, Ph.D.
Proposal No. IBD-0064
Applicant Organization: University of Southampton (United Kingdom)
Project Title: Functional role of human macrophage metalloelastase in inflammatory bowel disease
Period of Award: January 1, 2004 – August 31, 2007
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Principal Investigator: Phanstiel, Otto, Ph.D.
Proposal No. IBD-0090R
Applicant Organization: University of Central Florida (U.S.A.)
Project Title: Development of polyamine conjugates as sensitive probes to explore inflammatory bowel disease processes
Period of Award: May 1, 2004 - February 28, 2007
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Principal Investigator: Plevy, Scott, M.D.
Proposal No. IBD-0110
Applicant Organization: University of Pittsburgh (U.S.A.)
Project Title: Clostridium perfringens as a novel therapeutic vehicle in inflammatory bowel disease
Period of Award: August 1, 2004 - January 31, 2006
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Principal Investigator: Rottiers, Pieter, Ph.D. (replacement PI)Cuvelier, Claude, M.D., Ph.D. (original PI)
Proposal No. IBD-0123
Applicant Organization: Flanders Interuniversity Institute for Biotechnology vzw (replacement organization - Belgium)
Ghent University (original organization - Belgium)
Project Title: Treatment of experimental colitis by camelid antibody fragments: local delivery by genetically engineered lactococci administration and evaluation of their therapeutic potential
Period of Award: July 1, 2004 - June 30, 2006
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Principal Investigator: Siegmund, Britta, M.D.
Proposal No. IBD-0108
Applicant Organization: Charité Universitätsmedizin Berlin, Campus Benjamin Franklin (Germany)
Project Title: Specific inhibition of histone deacetylases as a novel anti-inflammatory and anti-proliferative approach in experimental colitis in mice
Period of Award: April 1, 2004 – July 31, 2006
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Principal Investigator: Smyrk, Thomas C., M.D.
Proposal No. IBD-0075R2
Applicant Organization: Mayo Clinic Rochester (U.S.A.)
Project Title: HLA typing and expression: potential marker for identifying early dysplasia and stratifying the risk for inflammatory bowel disease-cancer
Period of Award: July 15, 2004 – May 31, 2007
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