Grant Publications

Proposal No. IBD-0080R
Principal Investigator:  Robert W. Colman, M.D.
Applicant Organization:  Temple University (Philadelphia, Pennsylvania, U.S.A.)
Project Title:  Kallikrein-kinin system in inflammatory bowel disease
Period of Award:  January 1, 2004 - December 31, 2006

Isordia-Salas I, Pixley RA, Sainz IM, Martinez-Murillo C, Colman RW.  The role of plasma high molecular weight kininogen in experimental intestinal and systemic inflammation.  Archives of Medical Research 2004;35:369-77.

Devani M, Vecchi M, Ferrero S, Avesani EC, Arizzi C, Chao L, Colman RW, Cugno M. Kallikrein-kinin system in inflammatory bowel diseases: intestinal involvement and correlation with the degree of tissue inflammation.  Digestive and Liver Disease 2005; 37:665-73.

Keith JC Jr, Sainz Im, Isordia-Salas I, Pixley RA, Leathurby Y, Albert LM, Colman RW.  A monoclonal antibody against kininogen reduces inflammation in the HLA-B27 transgenic rat.  Arthritis Research & Therapy 2005;7:R769-76.

Stadnicki A, Pastucha E, Nowaczyk G, Mazurek U, Plewka D, Machnik G, Wilczok T, Colman RW.  Immunolocalization and expression of kinin B1R and B2R receptors in human inflammatory bowel disease.  American Journal of Physiology - Gastrointestinal and Liver Physiology 2005;289:G361-6.

Khan M, Bradford H, Isordia-Salas I, Liu Y, Wu Y, Espinola R, Ghebrehiwet B, Colman R.  High-molecular-weight kininogen fragments stimulate the secretion of cytokines and chemokines through uPAR, Mac-1, and gC1qR in monocytes.  Arteriosclerosis, Thrombosis, and Vascular Biology 2006;26:2260-6.