Grant Publications

Proposal No. IBD-0090R
Principal Investigator:   Otto Phanstiel, Ph.D.
Applicant Organization:  University of Central Florida (Orlando, U.S.A.)
Project Title:  Development of polyamine conjugates as sensitive probes to explore inflammatory bowel disease processes
Period of Award:  May 1, 2004 - February 28, 2007

Breitbeil F, Kaur N, Delcros JG, Martin B, Abboud KA, Phanstiel O.  Modeling the preferred shapes of polyamine transporter ligands and dihydromotuporamine-C mimics: shovel versus hoe.  Journal of Medicinal Chemistry 2006;49:2407-16.

Gardner RA, Belting M, Svensson K, Phanstiel O.  Synthesis and transfection efficiencies of new lipophilic polyamines.  Journal of Medicinal Chemistry 2007;50:308-18.

Geden SE, Gardner RA, Fabbrini MS, Ohashi M, Phanstiel O, Teter K.  Lipopolyamine treatment increases the efficacy of intoxication with saporin and an anticancer saporin conjugate.  FEBS Journal 2007;274:4825-36.

Kaur N, Delcros JG, Archer J, Weagraff NZ, Martin B, Phanstiel O.  Designing the polyamine pharmacophore: influence of N-substituents on the transport behavior of polyamine conjugates.  Journal of Medicinal Chemistry 2008;51:2551-60.

Kaur N, Delcros JG, Imran J, Khaled A, Chehtane M, Tschammer N, Martin B, Phanstiel O.  A comparison of chloroambucil- and xylene-containing polyamines leads to improved ligands for accessing the polyamine transport system.  Journal of Medicinal Chemistry 2008;51:1393-1401.

Tsen C, Iltis M, Kaur N, Bayer C, Delcros JG, von Kalm L, Phanstiel O.  A Drosophila model to identify polyamine-drug conjugates that target the polyamine transporter in an intact epithelium.  Journal of Medicinal Chemistry 2008;51:324-30.