Grant Publications

Proposal No. IBD-0102
Principal Investigator:  Andrew T. Gewirtz, Ph.D.
Applicant Organization:  Emory University (Atlanta, Georgia, U.S.A.)
Project Title:  Adaptive immunity to flagellin in inflammatory bowel disease
Period of Award:  May 1, 2004 – April 30, 2006

Sitaraman SV, Klapproth JM, Moore DA 3rd, Landers C, Targan S, Williams IR, Gewirtz AT.  Elevated flagellin-specific immunoglobulins in Crohn's disease.  American Journal of Physiology - Gastrointestinal and Liver Physiology 2005;288:403-6.

Gewirtz AT, Vijay-Kumar M. Brant SR, Duerr RH, Nicolae DL, Cho JH.  Dominant-negative TLR5 polymporphism reduces adaptive immune response to flagellin and negatively associates with Crohn's disease.  American Journal of Physiology - Gastrointestinal and Liver Physiology 2006;290:G1157-63.

Sanders CJ, Yu Y, Moore DA 3rd, Williams IR, Gewirtz AT.  Humoral immune response to flagellin requires T cells and activation of innate immunity.  The Journal of Immunology 2006;177:2810-18.

Vijay-Kumar M, Sanders CJ, Taylor RT, Kumar A, Aitken DJ, Sitaraman SV, Neish AS, Uematsu S, et al.  Deletion of TLR5 results in spontaneous colitis in mice.  Journal of Clinical Investigation 2007;117:3909-21.