Grant Publications

Proposal No.   IBD-0106
Principal Investigator:  Lillian Maggio-Price, V.M.D., Ph.D.
Applicant Organization:   University of Washington (Seattle, U.S.A.)
Project Title:  Molecular mechanism of colon carcinogenesis:  collaborative effects of Helicobacter infection and TGF-β dysregulation
Period of Award:  May 1, 2004 – November 30, 2006

Maggio-Price L, Bielefeldt-Ohmann H, Treuting P, Iritani BM, Zeng W, Nicks A, Tsang M, Shows D, Morrissey P, Viney JL.  Dual infection with Helicobacter bilis and Helicobacter hepaticus in p-glycoprotein-deficient mdr1a^-/- mice results in colitis that progresses to dysplasia.  American Journal of Pathology 2005;166:1793-1806.

Maggio-Price L, Treuting P, Zeng W, Tsang M, Bielefeldt-Ohmann H, Iritani BM.  Helicobacter infection is required for inflammation and colon cancer in SMAD3-deficient mice.  Cancer Research 2006;66:828-38.

Torrence AE, Brabb T, Jviney JL, Bielefeldt-Ohmann H, Treuting P, Seamons A, Drivdahl R, Zeng W, Maggio-Price L.  Serum biomarkers in a mouse model of bacterial-induced inflammatory bowel disease.  Inflammatory Bowel Diseases 2008;14:480-90.

Maggio-Price L, Treuting P, Bielefeldt-Ohmann H, Seamon A, Drivdahl R, Zeng W, Lai L, Huycke M, Phelps S, Brabb T, Iritani BM.  Bacterial infection of Smad3/Rag2 double-null mice with TGFbeta dysregulation as a model for studying inflammation-associated colon cancer.  American Journal of Pathology 2009;174:317-29.