Grant Publications

Proposal No.   IBD-0108
Principal Investigator:  Britta Siegmund, M.D.
Applicant Organization:   Charité Universitätsmedizin Berlin, Campus Benjamin Franklin (Germany)
Project Title:  Specific inhibition of histone deacetylases as a novel anti-inflammatory and anti-proliferative approach in experimental colitis in mice
Period of Award:  April 1, 2004 – July 31, 2006

Siegmund B, Zeitz M.  Transglutaminases:  new target molecules for inflammatory bowel disease?  Gut 2005;54:443-4.

Glauben R, Batra A, Fedke I, Zeitz M, Lehr HA, Leoni F, Mascagni P, Fantuzzi G, Dinarello CA, Siegmund B.  Histone hyperacetylation is associated with amelioration of experimental colitis in mice.  Journal of Immunology 2006;176:5015-22.

Glauben R, Batra A, Stroh T, Erben U, Fedke I, Lehr HA, Leoni F, Mascagni P, et al. Histone deacetylases: novel targets for prevention of colitis-associated cancer in mice.  Gut 2008;57:613-22.

Glauben R, Siegmund B.  Molecular basis of histone deacetylase inhibitors as new drugs for the treatment of inflammatory bowel disease and cancer.  Methods in Molecular Biology and Molecular Medicine 2009;512:365-76.

Glauben R, Sonnenberg E, Zeitz M, Siegmund B.  HDAC inhibitors in models of inflammation-related tumorigenesis.  Cancer Letters 2009;280:154-9.