Grant Publications

Proposal No.  IBD-0119R2
Principal Investigator:  Xuhang Li, Ph.D.
Applicant Organization:  Johns Hopkins University (Baltimore, Maryland, U.S.A.)
Project Title:  Initial proteomic studies of inflammatory bowel diseases
Period of Award:  January 1, 2005 – December 31, 2007

Li X, Conklin L, Alex P.  New serological biomarkers of inflammatory bowel diseases.  World Journal of Gastroenterology 2008;14:5115-24.

Li X, Donowitz M.  Fractionation of subcellular membrane vesicles of epithelial and nonepithelial cells by OptiPrep density gradient ultracentrifugation.  Methods in Molecular Biology and Molecular Medicine 2008;440:97-110.

Sarker R, Grønborg M, Cha B, Mohan S, Chen Y, Pandey A, Litchfield D, Donowitz M, Li X.  Casein kinase 2 binds to the C terminus of Na+/H+ exchanger 3 (NHE3) and stimulates NHE3 basal activity by phosphorylating a separate site in NHE3.  Molecular Biology of the Cell 2008;19:3859-70.

Alex P, Gucek M, Li X.  Applications of proteomics in the study of inflammatory bowel diseases: current status and future potential with available technologies.  Inflammatory Bowel Diseases 2009;15:616-29.

Alex P, Zacho NC, Nguyen T, Gonzales L, Chen TE, Conklin LS, Centola M, Li X.  Distinct cytokine patterns identified from multiplex profiles of murine DSS and TNBS-induced colitis.  Inflammatory Bowel Diseases 2009;15:341-52.

Chen CS, Sullivan S, Anderson T, Tan AC, Alex PJ, Brant SR, Cuffari C, Bayless TM, Talor MV, Burek CL, Wang H, Li R, Datta LW, Wu Y, Winslow RL, Zhu H, Li X.  Identification of novel serological biomarkers for inflammatory bowel disease using Escherichia coli proteome chip.  Molecular and Cellular Proteomics 2009;8:1765-76.

Sullivan S, Alex P, Dassopoulos T, Zachos NC, Iacobuzio-Donahue C, Donowitz M, Brant SR, Cuffari C, Harris ML, Datta LW, Conklin L, Chen Y, Li X.  Downregulation of sodium transporters and NHERF proteins in IBD patients and mouse colitis models: potential contributors to IBD-associated diarrhea.  Inflammatory Bowel Diseases 2009;15:261-74.

Alex P, Ye M, Zachos NC, Sipes J, Nguyen T, Suhodrev M, Gonzales L, Arora Z, Zhang T, Centola M, Guggino SE, Li X.  Clcn5 knockout mice exhibit novel immunomodulatory effects and are more susceptible to dextran sulfate sodium-induced colitis.  Journal of Immunology 2010;184:3988-96.