Grant Publications

Proposal No.  IBD-0140
Principal Investigator:  Silvio Danese, M.D.
Applicant Organization:  Catholic University of Rome (Italy)
Project Title:  Angiogenesis in inflammatory bowel disease:  the contribution of platelet-endothelial interactions and implications for novel therapeutic approaches
Period of Award:  February 1, 2005 – February 28, 2007

Danese S, Fiocchi C.  Platelet activation and the CD40/CD40 ligand pathway:  mechanisms and implications for human disease.  Critical Reviews in Immunology 2005;25:1003-21.

Danese S, Semeraro S, Marini M, Roberto I, Armuzzi A, Papa A, Gasbarrini A.  Adhesion molecules in inflammatory bowel disease:  therapeutic implications for gut inflammation.  Digestive and Liver Disease 2005;37:811-8.

Danese S, Fiocchi C. Etiopathogenesis of inflammatory bowel diseases.  World Journal of Gastroenterology 2006;12:4807-12.

Danese S, Sans M, Scaldaferri F, Sgambato A, Rutella S, Cittadini A, Pique JM, Panes J, et al.  TNF-alpha blockage downregulates the CD40/CD40L pathway in mucosal microcirculation:  a novel anti-inflammatory mechanism of infliximab in Crohn's disease.  Journal of Immunology 2006;176:2617-24.

Danese S, Sans M, de la Motte C, Pola R, Rivera-Reyes BM, West G, Philips MH, Willis J, et al.  Angiogenesis as a novel component of inflammatory bowel disease pathogenesis.  Gastroenterology 2006;130:2060-73.

Danese S.  Inflammation and the mucosal microcirculation in inflammatory bowel disease: the ebb and flow.  Current Opinon in Gastroenterology 2007;23:384-9.

Danese S, Dejana E, Fiocchi C.  Immune regulation by microvascular endothelial cells: directing innate and adaptive immunity, coagulation, and inflammation.  The Journal of Immunology 2007;178:6017-22.

Danese S, Papa A, Saibeni S, Repici A, Malesci A, Vecchi M.  Inflammation and coagulation in inflammatory bowel disease:  the clot thickens.  American Journal of Gastroenterology 2007:102:174-86.

Danese S, Sans M, Spencer DM, Beck I, Doñate F, Plunkett ML, de la Motte C, Redline R, Shaw DE, Levine AD, Mazar AP, Fiocchi C. Angiogenesis blockade as a new therapeutic approach to experimental colitis. Gut 2007;56:855-62.

Danese S, Scaldaferri F, Vetrano S, Stefanelli T, Graziani C, Repici A, Ricci R, Straface G, Sgambato A, Malesci A, Fiocchi C, Rutella S.  Critical role of the CD40-CD40 ligand pathway in governing mucosal inflammation-driven angiogenesis in inflammatory bowel disease.  Gut 2007;56:1248-56.

Scaldaferri F, Sans M, Vetrano S, Graziani C, De Cristofaro R, Gerlitz B, Repici A, Arena V, et al.  Crucial role of the protein C pathway in governing microvascular inflammation in inflammatory bowel disease.  Journal of Clinical Investigation 2007;117:1951-60.

Danese S.  Negative regulators of angiogenesis in inflammatory bowel disease: thrombospondin in the spotlight.  Pathobiology 2008;75:22-4.

Deban L, Correale C, Vetrano S, Malesci A, Danese S.  Multiple pathogenic roles of microvasculature in inflammatory bowel disease: a Jack of all trades.  American Journal of Pathology 2008;172:1457-66.

Stefanelli T, Malesci A, De La Rue SA, Danese S.  Anti-adhesion molecule therapies in inflammatory bowel disease: touch and go.  Autoimmunity Reviews 2008;7:364-39.