Grant Publications

Proposal No.  IBD-0160
Principal Investigator:  Atsushi Mizoguchi, M.D., Ph.D.
Applicant Organization:  Massachusetts General Hospital (Boston, U.S.A.)
Project Title:  Therapeutic approach using interleukin-22 in experimental colitis
Period of Award:  November 1, 2005 – April 30, 2008

Mizoguchi A, Ogawa A, Takedatsu H, Sugimoto K, Shimomura Y, Shirane K, Nagahama K, Nagaishi T, et al. Dependence of intestinal granuloma formation on unique myeloid DC-like cells.  Journal of Clinical Investigation 2007;117:305-15.

Mizoguchi E, Mizoguchi A.  Is the sugar always sweet in intestinal inflammation?  Immunologic Research 2007;37:47-60.

Sugimoto K, Ogawa A, Shimomura Y, Nagahama K, Mizoguchi A, Bhan AK.  Inducible IL-12-producing B cells reguate Th2-mediated intestinal inflammation.  Gastroenterology 2007;133:124-26.

Mizoguchi A, Mizoguchi E.  Inflammatory bowel disease, past, present and future, lesson from animal models.  Journal of Gastroenterology 2008;43:1-17.

Mizoguchi E, Hachiya Y, Kawada M, Nagatani K, Ogawa A, Sugimoto K, Mizoguchi A, Podolsky DK.  TNF receptor type I-dependent activation of innate responses to reduce intestinal damage-associated mortality.  Gastroenterology 2008;134:470-80.

Nagahama K, Ogawa A, Shirane K, Shimomura Y, Sugimoto K, Mizoguchi A.  Protein kinase C theta plays a fundamental role in different types of chronic colitis.  Gastroenterology 2008;134:459-69.

Shimomura Y, Mizoguchi E, Sugimoto K, Kibe R, Benno Y, Mizoguchi A, Bhan AK.  Regulatory role of B-1 B cells in chronic colitis.  International Immunology 2008;20:729-27.

Shimomura Y, Ogawa A, Sugimoto K, Kawada M, Mizoguchi E, Shi HN, Pillai S, Bhan AK, Mizoguchi A.  A unique B-2 B cell subset in the intestine.  Journal of Experimental Medicine 2008;205:1343-55.

Sugimoto K, Ogawa A, Mizoguchi E, Shimomura Y, Andoh A, Bhan AK, Blumberg RS, Xavier RJ, Mizoguchi A.  IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colits.  Journal of Clinical Investigation 2008;118:534-44.
 
Mizoguchi A, Mizoguchi E.  Animal models of IBD: linkage to human disease.  Curr Opin Pharmacol 2010 Oct;10(5):578-87.