Grant Publications

Proposal No. IBD-0164R
Principal Investigator:  Carsten Büning, M.D.
Applicant Organization:  Charité, Campus Mitte, Universitätsmedizin Berlin (Germany)
Project Title:  Genes involved in epithelial integrity as risk factors for inflammatory bowel disease?
Period of Award:  June 1, 2006 – April 30, 2009

Baumgart DC, Buening C, Geerdts L, Schmidt HH, Genschel J, Fiedler T, Gentz E, Molnar T, et al. The c.1-260C 1 T promoter variant of CD14 but not the c.896A 1 G (p.D299G) variant of toll-like receptor 4 (TLR4) genes is associated with inflammatory bowel disease.  Digestion 2007;76:196–202.

Buening C, Durmus T, Molnar T, de Jong DJ, Drenth JP, Fiedler T, Gentz E, Todorov T, et al. A study in three European IBD cohorts confirms that the ATG16L1 c.898A>G (p.Thr300Ala) variant is a susceptibility factor for Crohn's disease  Journal of Crohn's and Colitis 2007;1:70-6.

Buening C, Schmidt HH, Molnar T, de Jong D, Fiedler T, Buhner S, Sturm A, Baumgart DC, et al.  Heterozygosity for IL23R p.Arg381Gln confers a protective effect against Crohn's disease but also against ulcerative colitis.  Alimentary Pharmacology & Therapeutics 2007;26:1025-33.

Buening C, Schmidt HH, Molnar T, Drenth JP, Fiedler T, Gentz E, Todorov T, Baumgart DC, et al.  No association of the CARD8 (TUCAN) c.30T>A (p.C10X) variant with Crohn's disease: A study in three independent European cohorts.  Inflammatory Bowel Diseases 2008;14:332-7.