Grant Publications

Proposal No. IBD-0176R
Principal Investigator:  Huabao Xiong, Ph.D.
Applicant Organization:  Mount Sinai School of Medicine (New York, New York, U.S.A.)
Project Title:   Blocking TLR signaling pathway by TLR peptides in the treatment of colitis
Award Period:  March 15, 2006 – March 14, 2008

Gu Y, Yang J, Ouyang X, Liu W, Li H, Yang J, Bromberg J, Chen S, et al.  Interleukin-10 inhibits Th17 cytokines in macrophages and T cells.  European Journal of Immunology 2008;38:1807-1813.

Huang B, Zhao J, Unkeless J, Feng Z, Xiong H.  TLR signaling by tumor and immune cells: a double edge sword.  Oncogene 2008;27:218-24.

Yang J, Yang M, Htut TM, Ouyang X, Hanidu A, Li X, Sellati R, Jiang H, Zhang S. Li H, Zhao J, Ting AT, Mayer L, Unkeless JC, Labadia ME, Hodge M, Li J, Xiong H.  Epstein-Barr virus-induced gene 3 negatively regulates IL-17, IL-22 and RORgamma t.  European Journal of Immunology 2008;38:1204-14.

Liu W, Ouyang X, Yang J, Liu J, Li Q, Gu Y, Fukata M, Lin T, et al.  AP-1 activated by Toll-like receptors regulates expression of IL-23 p19.  Journal of Biological Chemistry 2009;284:24006-16.

Ouyang X, Yang Z, Zhang R, Arnaboldi P, Lu G, Li Q, Wang W, Zhang B, Cui M, Zhang H, Liang-Chen J, Qin L, Zheng F, Huang B, Xiong H.  Potentiation of Th17 cytokines in aging process contributes to the development of colitis.  Cellular Immunology 2011;266:208-17.