Grant Publications

Proposal No. IBD-0187
Principal Investigator:  Timothy Orchard, M.D.
Applicant Organization:  Imperial College of Science, Technology and Medicine (London, United Kingdom)
Project Title:   The use of metabonomic technology (nuclear magnetic resonance spectroscopy) in the investigation of Crohn’s disease
Period of Award:  September 1, 2006 – August 31, 2009

Cobbold JF, Anstee QM, Goldin RD, Williams HR, Matthews HC, North BV, Absalom N, Thomas HC, Thursz MR, Cox RD, Taylor-Robinson SD, Cox IJ.  Phenotyping murine models of non-alcoholic fatty liver disease through metabolic profiling of intact liver tissue.  Clinical Science 2009;116:403-413.

Williams HR, Cox J, North BV, Patel VM, Marshall Se, Jewell DP, Ghosh S, Thomas HJ, et al.  Characterization of inflammatory bowel disease with urinary metabolic profiling.  American Journal of Gastroenterology 2009;104:1435-44.

Sato H, Williams HR, Spagnolo P, Abdallah A, Ahmad T, Orchard TR, Copley SJ, Desai SR, Wells AU, du Bois RM, Welsh KI.  CARD15/NOD2 polymorphisms are associated with severe pulmonary sarcoidosis.  European Respiratory Journal 2010;35:324-30.

Williams HR, Cox IJ, Walker DG, Cobbold JF, Taylor-Robinson SD, Marshall SE, Orchard TR.  Differences in gut microbial metabolism are responsible for reduced hippurate synthesis in Crohn's disease.  BMC Gastroenterology 2010;10:108.

Walker DG, Williams HR, Kane SP, Mawdsley JE, Arnold J, McNeil I, Thomas HJ, Teare JP, Hart AL, Pitcher MC, Walters JR, Marshall SE, Orchard TR.  Differences in inflammatory bowel disease phenotype between South Asians and Northern Europeans living in North West London, UK.  American Journal of Gastroenterology 2011;106:1281-9.