Grants Funded in 2007

Principal Investigator: Bossuyt, Xavier, M.D., Ph.D.
Proposal No. IBD-0202
Applicant Organization: Katholieke Universiteit Leuven (Belgium)
Project Title: Identification of target antigens of antibodies in inflammatory bowel disease
Period of Award: May 1, 2007 – April 30, 2009
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Principal Investigator: Cao, Caroline, Ph.D.
Proposal No. IBD-0196R
Applicant Organization: Tufts University (U.S.A.)
Project Title: Image-guided research in colonoscopy to improve diagnosis of inflammatory bowel disease
Period of Award: February 1, 2007 – January 31, 2009
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Principal Investigator: Croese, John, MBBS, M.D.
Proposal No. IBD-0214R
Applicant Organization: Queensland Institute of Medical Research (Australia)
Project Title: Inoculating celiac disease patients with the human hookworm Necator americanus: evaluating immunity and gluten sensitivity
Period of Award: December 1, 2007 – November 30, 2009
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Principal Investigator: Daunert, Sylvia, Pharm.D., Ph.D.
Proposal No. IBD-0198R
Applicant Organization: University of Kentucky Research Foundation (U.S.A.)
Project Title: Non-invasive biosensors for the diagnosis and management of Crohn's disease
Period of Award: June 1, 2007 – May 31, 2008
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Principal Investigator: Denson, Lee A., M.D.
Proposal No. IBD-0211
Applicant Institution: Cincinnati Children's Hospital Medical Center (U.S.A.)
Project Title: GM-CSF bioactivity and IBD phenotype
Period of Award: October 1, 2007 - September 30, 2009
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Principal Investigator: Fayad, Raja, M.D.
Proposal No. IBD-0199R
Applicant Institution: The Board of Trustees of the University of Illinois (U.S.A.)
Project Title: Adipose tissue macrophages: role in the development of strictures in Crohn's disease
Period of Award: October 1, 2007 - September 30, 2008
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Principal Investigator: Föll, Dirk, M.D.
Proposal No. IBD-0201R
Applicant Institution: University Hospital of Münster (Germany)
Project Title: Functional characterization of GM-CSF induced monocyte subsets and analysis of their relevance in Crohn's disease
Period of Award: September 1, 2007 - February 28, 2009
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Principal Investigator: Guillemin, Karen J., Ph.D.
Proposal No. IBD-0209
Applicant Institution: University of Oregon (U.S.A.)
Project Title: Do changes in gut motility promote gut inflammation by altering the composition of gut microbiota?
Period of Award: August 1, 2007 - February 28, 2009
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Principal Investigator: Hurlstone, David Paul, MB ChB, M.D.
Proposal No. IBD-0219
Applicant Institution: Sheffield Teaching Hospitals NHS Foundation Trust (United Kingdom)
Project Title: A randomized Phase II clinical trial to investigate the diagnostic utility of confocal chronoscopic endomicroscopy for the detection and characterization of intraepithelial neoplasia in chronic ulcerative colitis
Period of Award: October 8, 2007 - October 7, 2008
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Principal Investigator: Jensen, Liselotte, Ph.D.
Proposal No. IBD-0192R
Applicant Organization: University of Pennsylvania (U.S.A.)
Project Title: Interleukin-1 system in inflammatory bowel disease and implications for the development of novel therapies
Period of Award: March 1, 2007 – February 28, 2010
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Principal Investigator: Kaplan, Gilaad G., M.D., M.P.H.
Proposal No. IBD-0216R
Applicant Organization: University of Calgary (Canada)
Project Title: The effect of air pollution on the development of Crohn's disease and ulcerative colitis in England and Wales
Period of Award: September 1, 2007 – August 31, 2008
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Principal Investigator: Kwon, John H., M.D., Ph.D.
Proposal No. IBD-0212
Applicant Organization: Johns Hopkins University (U.S.A.)
Project Title: The differential expression of microRNA in ulcerative colitis patients and their regulation of MIP-2α expression
Period of Award: July 1, 2007 – July 31, 2009
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Principal Investigator: Ma, Xiaojing, Ph.D.
Proposal No. IBD-0210R2
Applicant Institution: Weill Medical College of Cornell University (U.S.A.)
Project Title: The Crohn’s disease-associated NOD23020insC mutant has an acquired activity as an inhibitor of IL-10 production
Award Period: October 1, 2007 - September 30, 2008
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Principal Investigator: Montgomery, Scott M., Ph.D.
Proposal No. IBD-0204R2
Applicant Organization: Karolinska Institutet (Sweden)
Project Title: Markers of perinatal bowel colonization and pediatric Crohn's disease risk
Period of Award: September 1, 2007 – February 28, 2009
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Principal Investigator: Powrie, Fiona M., DPhil
Proposal No. IBD-0203
Applicant Organization: University of Oxford (United Kingdom)
Project Title: Role of TGF-β in the pathogenesis of IBD
Period of Award: August 1, 2007 – July 31, 2009
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Principal Investigator: Rampton, David S., DPhil
Proposal No. IBD-0213R
Applicant Organization: Queen Mary and Westfield College, University of London (United Kingdom)
Project Title: Hypnotherapy for prevention of relapse in ulcerative colitis: a randomized, single-blinded, controlled clinical trial
Period of Award: October 1, 2007 – September 30, 2009
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Principal Investigator: Ramratnam, Bharat, M.D.
Proposal No. IBD-0194R
Applicant Organization: Rhode Island Hospital (U.S.A.)
Project Title: Transient gene therapy for inflammatory bowel disease
Period of Award: March 15, 2007 – March 14, 2009
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Principal Investigator: Sanderson, Jeremy D., M.D.
Proposal No. IBD-0215R
Applicant Organization: King's College London (United Kingdom)
Project Title: The persistence of bacteria in lamina propria macrophages in Crohn's disease: role in pathogenesis
Period of Award: November 1, 2007 – April 30, 2009
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Principal Investigator: Savidge, Tor C., Ph.D.
Proposal No. IBD-0188R
Applicant Organization: University of Texas Medical Branch at Galveston (U.S.A.)
Project Title: To examine the therapeutic potential of a novel mucosal barrier-inducing factor in the treatment of Crohn's disease
Period of Award: March 1, 2007 – February 29, 2008
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Principal Investigator: Shen, Bo, M.D., M.S.
Proposal No. IBD-0218
Applicant Organization: The Cleveland Clinic Foundation (U.S.A.)
Project Title: Pouchitis: a human model for bacteria-host interaction in inflammatory bowel disease
Period of Award: November 1, 2007 – October 31, 2008
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Principal Investigator: Sturm, Andreas, M.D.
Proposal No. IBD-0186R
Applicant Organization: Charité - Universitätsmedizin Berlin (Germany)
Project Title: Galectin-2: Evaluation of a novel anti-inflammatory approach in the treatment of inflammatory bowel disease
Period of Award: January 1, 2007 – December 31, 2008
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Principal Investigator: Segal, Anthony W., M.D., Ph.D., D.Sc.
Proposal No. IBD-0193R
Applicant Organization: University College London (United Kingdom)
Project Title: Impaired innate immunity and the pathogenesis of Crohn's disease
Period of Award: March 1, 2007 – February 29, 2008
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