Grant Publications

Proposal No. IBD-0186R
Principal Investigator:  Andreas Sturm, M.D.
Applicant Organization:  Charité - Universitätsmedizin Berlin (Germany)
Project Title:  Galectin-2:  Evaluation of a novel anti-inflammatory approach in the treatment of inflammatory bowel disease
Period of Award:  January 1, 2007 – December 31, 2008

Paclik D, Berndt U, Danese S, Wiedenmann B, Dignass AU, Sturm A.  Galectin-4 controls intestinal inflammation by selective regulation of peripheral and mucosal T cell apoptosis and cell cycle.  PLoS ONE 2008;3:e2629.

Paclik D, Berndt U, Guzy C, Dankof A, Danese S, Holzloehner P, Rosewicz S, Wiedenmann B, Wittig BM, Dignass AU, Sturm A. Galectin-2 induces apoptosis of lamina propria T lymphocytes and ameliorates acute chronic experimental colitis in mice. Journal of Molecular Medicine 2008;86:1395-406.

Paclik D, Lohse K, Wiedenmann B, Dignass A, Sturm A.  Galectin-2 and -4, but not galectin-1, promote intestinal epithelial wound healing in vitro through a TGF-beta-independent mechanism.  Inflammatory Bowel Diseases 2008;14:1366-72.