Grant Publications

Proposal No. IBD-0188R
Principal Investigator:  Tor C. Savidge, Ph.D.
Applicant Organization:  University of Texas Medical Branch at Galveston (U.S.A.)
Project Title:  To examine the therapeutic potential of a novel mucosal barrier-inducing factor in the treatment of Crohn's disease
Period of Award:  March 1, 2007  – February 29, 2008

Hoogerwerf WA, Hellmich HL, Cornélissen G, Halberg F, Shahinian VB, Bostwick J, Savidge TC, Cassone VM.  Clock gene expression in the murine gastrointestinal tract: endogenous rhythmicity and effects of a feeding regimen.  Gastroenterology 2007;133:1250-60.

Savidge T, Neunlist M, Sofroniew M.  Glial cells and barrier funcations: another gut-brain paradigm.  Glial Cells in Health and Disease - The VIII European Meeting 2007;41-6.

Savidge TC.  MIND the gap: an astroglial perspective on barrier regulation.  Neuron Glia Biology 2007;3:191-7.

Savidge TC, Newman P, Pothoulakis C, Ruhl A, Neunlist M, Bourreille A, Hurst R, Sofroniew MV.  Enteric glia regulate intestinal barrier function and inflammation via release of S-nitrosoglutathione.  Gastroenterology 2007;132:1344-58.

Savidge TC, Sofroniew MV, Neunlist M.  Starring roles for astroglia in barrier pathologies of gut and brain.  Laboratory Investigation 2007;87:731-6.

Kumar T, Savidge TC.  Enteric neuropathy: NO, SNO in AGEs.  The Open Gastroenterology Journal 2008;2:11-7.

Neunlist M, Van Landeghem L, Bourreille A, Savidge T.  Neuro-glial crosstalk in inflammatory bowel disease.  Journal of Internal Medicine 2008;263:577-83.

Flamant M, Aubert P, Rolli-Derkinderen M, Bourreille A, Neunlist MR, Mahé MM, Meurette G, Marteyn B, Savidge T, Galmiche JP, Sansonetti PJ, Neunlist M.  Enteric glia protect against Shigella flexneri invasion in intestinal epithelial cells: a role for S-nitrosoglutathione.  Gut 2011;60:473-84.

Savidge TC.  S-nitrosothiol signals in the enteric nervous system: lessons learnt from big brother.  Frontiers in Neuroscience 2011;5:31.

Savidge TC, Urvil P, Oezguen N, Ali K, Choudhury A, Acharya V, Pinchuk I, Torres AG, English RD, Wiktorowicz JE, Loeffelholz M, Kumar R, Shi L, Nie W, Braun W, Herman B, Hausladen A, Feng H, Stamler JS, Pothoulakis C.  Host S-nitrosylation inhibits clostridial small molecule-activated glucosylating toxins.  Nature Medicine 2011;17:1136-41.

Van Landeghem L, Chevalier J, Mahé MM, Wedel T, Urvil P, Derkinderen P, Savidge T, Neunlist M.  Enteric glia promote intestinal mucosal healing via activation of focal adhesion kinase and release of proEGF.  American Journal of Physiology - Gastrointestinal and Liver Physiology 2011;300:G976-87.

Wiktorowicz JE, Stafford S, Rea H, Urvil P, Soman K, Kurosky A, Perez-Polo JR, Savidge TC.  Quantification of cysteinyl S-nitrosylation by fluorescence in unbiased proteomic studies.  Biochemistry 2011;50:5601-14.