Grant Publications

Proposal No. IBD-0224R2
Principal Investigator:   Silvio Danese, M.D., Ph.D.
Applicant Organization:  Fondazione Humanitas per La Ricerca (Milan, Italy)
Project Title:  The role of lymphangiogenesis in inflammatory bowel disease pathogenesis
Period of Award:  April 1, 2008 – September 30, 2010

Vetrano S, Rescigno M, Cera MR, Correale C, Rumio C, Doni A, Fantini M, Sturm A, Borroni E, Repici A, Locati M, Malesci A, Dejana E, Danese S.  Unique role of junctional adhesion molecule-A in maintaining mucosal homeostasis in inflammatory bowel disease.  Gastroenterology 2008;135:173-84.

Danese S. Nonimmune cells in inflammatory bowel disease: from victim to villain. Trends in Immunology 2008;29:555-64.

Scaldaferri F, Sans M, Vetrano S, Correale C, Arena V, Pagano N, Rando G, Romeo F, Potenza AE, Repici A, Malesci A, Danese S.  The role of MAPK in governing lymphocyte adhesion to and migration across the microvasculature in inflammatory bowel disease.  European Journal of Immunology 2009;39:290-300.

Scaldaferri F, Vetrano S, Sans M, Arena V, Straface G, Stigliano E, Repici A, Sturm A, Malesci A, Panes J, Yla-Herttuala S, Fiocchi C, Danese S.  VEGF-A links angiogenesis and inflammation in inflammatory bowel disease pathogenesis.  Gastroenterology 2009;136:585-96.

Vetrano S, Danese S.  The role of JAM-A in inflammatory bowel disease: unrevealing the ties that bind.  Annals of the New York Academy of Sciences 2009;1165:308-13.

Danese S, Mantovani A.  Inflammatory bowel disease and intestinal cancer: a paradigm of the Yin-Yang interplay between inflammation and cancer.  Oncogene 2010;29:3313-23.

Danese S, Vetrano S, Zhang L, Ploplis VA, Castellino FJ.  The protein C pathway in tissue inflammation and injury: pathogenic role and therapeutic implications.  Blood 2010;115:1121-30.

Vetrano S, Borroni EM, Sarukhan A, Savino B, Bonecchi R, Correale C, Arena V, Fantini M, et al.  The lymphatic system controls intestinal inflammation and inflammation-associated colon cancer through the chemokine decoy receptor D6.  Gut 2010;59:197-206.

Danese S.  Immune and nonimmune components orchestrate the pathogenesis of inflammatory bowel disease.  American Journal of Physiology - Gastrointestinal and Liver Physiology 2011;300:G716-22.

Danese S.  Role of the vascular and lymphatic endothelium in the pathogenesis of inflammatory bowel disease: 'brothers in arms'.  Gut 2011;60:998-1008.

Rutella S, Fiorino G, Vetrano S, Correale C, Spinelli A, Pagano N, Arena V, Maggiano N, Repici A, Malesci A, Danese S.  Infliximab therapy inhibits inflammation-induced angiogenesis in the mucosa of patients with Crohn's disease.  American Journal of Gastroenterology 2011;106:762-70.