Grant Publications

Proposal No. IBD-0235
Principal Investigator: Lisa Ganley-Leal, Ph.D.
Applicant Organization: Boston Medical Center (Massachusetts, U.S.A.)
Project Title: Human B cells as potential mediators of inflammation in chronic inflammatory disease
Period of Award: November 1, 2008 – June 30, 2011

Jagannathan M, Hasturk H, Liang Y, Shin H, Hetzel JT, Kantarci A, Rubin D, McDonnell ME, et al.  TLR cross-talk specifically regulates cytokine production by B cells from chronic inflammatory disease patients.  Journal of Immunology 2009;183:7461-70.

Noronha AM, Liang YM, Hetzel JT, Hasturk H, Kantarci A, Stucchi A, Zhang Y, Nikolajczyk BS, et al.  Hyper-activated B cells in human inflammatory bowel disease.  Journal of Leukocyte Biology 2009;86:1007-16.

Ganley-Leal LM, Liang Y, Jagannathan-Bogdan M, Farraye FA, Nikolajczyk BS.  Differential regulation of TLR4 expression in human B cells and monocytes.  Molecular Immunology 2010;48:82-8.

Jagannathan M, McDonnell M, Liang Y, Hasturk H, Hetzel J, Rubin D, Kantarci A, Van Dyke TE, Ganley-Leal LM, Nikolajczyk BS.  Toll-like receptors regulate B cell cytokine production in patients with diabetes.  Diabetologia 2010;53:1461-71.

Liang Y, Hasturk H, Elliot J, Noronha A, Liu X, Wetzler LM, Massari P, Kantarci A, Winter HS, Farraye FA, Ganley-Leal LM.  Toll-like receptor 2 induces mucosal homing receptor expression and IgA production by human B cells.  Clinical Immunology 2011;138:33-40.

McDonnell M, Liang Y, Noronha A, Coukos J, Kasper DL, Farraye FA, Ganley-Leal LM.  Systemic toll-like receptor ligands modify B-cell responses in human inflammatory bowel disease.  Inflammatory Bowel Diseases 2011;17:298-307.