Grant Publications

Proposal No. IBD-0242
Principal Investigator:   Giovanni Monteleone, M.D., Ph.D.
Applicant Organization:  University of Rome "Tor Vergata" (Italy)
Project Title:  Antagonistic effects of interleukin-25 on CD14+ cell cytokine responses in the gut
Period of Award:  June 1, 2008 – June 30, 2010

Caruso R, Sarra M, Stolfi C, Rizzo A, Fina D, Fantini MC, Pallone F, MacDonald TT, Monteleone G.  Interleukin-25 inhibits interleukin-12 production and TH1 cell-driven inflammation in the gut.  Gastroenterology 2009;136:2270-9.

Caruso R, Stolfi C, Sarra M, Rizzo A, Fantini MC, Pallone F, Macdonald TT, Monteleone G.  Inhibition of monocyte-derived inflammatory cytokines by IL-25 occurs via p38 Map kinase-dependent induction of Socs-3.  Blood 2009;113:3512-19.

Monteleone G, Pallone F, Macdonald T.  Interleukin-21 (IL-21)-mediated pathways in T cell-mediated disease.  Cytokine & Growth Factor Reviews 2009;20:185-91.

Monteleone G, Pallone F, Macdonald TT.  Interleukin-25: A two-edged sword in the control of immune-inflammatory responses.  Cytokine & Growth Factor Reviews 2010;21:471-5. 

Stolfi C, Caruso R, Franzè E, Sarra M, De Nitto D, Rizzo A, Pallone F, Monteleone G.  Interleukin-25 fails to activate STAT6 and induce alternatively activated macrophages.  Immunology 2010;132:66-77.