Grant Publications

Proposal No. IBD-0246
Principal Investigator: Herbert W. Virgin, M.D., Ph.D.
Applicant Organization: Washington University (St. Louis, Missouri, U.S.A.)
Project Title: In vivo function of Crohn’s disease susceptibility gene ATG16L1 in intestinal inflammation
Period of Award: September 1, 2008 – February 28, 2011

Cadwell K, Liu JY, Brown SL, Miyoshi H, Loh J, Lennerz JK, Kishi C, Kc W, et al.  A key role for autophagy and the autophagy gene Atg16L1 in mouse and human intestinal Paneth cells.  Nature 2008;456:259-63.

Cadwell K, Patel KK, Komatsu M, Virgin HW, Stappenbeck TS.  A common role for Atg16L1, Atg5 and Atg7 in small intestinal Paneth cells and Crohn's disease.  Autophagy 2009;5:250-52.

Virgin HW, Levine B.  Autophagy genes in immunity.  Nature Immunology 2009;10:461-70.

Cadwell K, Patel KK, Maloney NS, Liu TC, Ng AC, Storer CE, Head RD, Xavier R, Stappenbeck TS, Virgin HW.  Virus-plus-susceptibility gene interaction determines Crohn's disease gene Atg16L1 phenotypes in intestine.  Cell 2010;141:1135-45.

Levine B, Mizushima N, Virgin HW.  Autophagy in immunity and inflammation.  Nature 2011;469:323-335.