Grant Publications

Proposal No. IBD-0294
Principal Investigator:  Mario S. Clerici, M.D.
Applicant Organization:  Università degli Studi di Milano (Italy)
Project Title:  Role of pathogen-driven selection in shaping the predisposition to inflammatory bowel disease: identification of disease susceptibility alleles
Period of Award:  September 1, 2010 - May 31, 2012

Cagliani R, Riva S, Pozzoli U, Fumagalli M, Comi GP, Bresolin N, Clerici M, Sironi M.  Balancing selection is common in the extended MHC region but most alleles with opposite risk profile for autoimmune diseases are neutrally evolving.  BMC Evolutionary Biology 2011;11:171.

Fumagalli M, Sironi M, Pozzoli U, Ferrer-Admetlla A, Pattini L, Nielsen R.  Signatures of environmental genetic adaptation pinpoint pathogens as the main selective pressure through human evolution.  PLoS Genetics 2011;7:e1002355.

Sironi M, Guerini FR, Agliardi C, Biasin M, Cagliani R, Fumagalli M, Caputo D, Cassinotti A, Ardizzone S, Zanzottera M, Bolognesi E, Riva S, Kanari Y, Miyazawa M, Clerici M.  An evolutionary analysis of RAC2 identifies haplotypes associated with human autoimmune diseases.  Molecular Biology and Evolution 2011;28:3319-29.

Guerini FR, Cagliani R, Forni D, Agliardi C, Caputo D, Cassinotti A, Galimberti D, Fenoglio C, Biasin M, Asselta R, Scarpini E, Comi GP, Bresolin N, Clerici M, Sironi M.  A functional variant in ERAP1 predisposes to multiple sclerosis.  PLoS One 2012;7:e29931.