Grant Publications

Proposal No. IBD-0304
Principal Investigator:  Emiko Mizoguchi, M.D., Ph.D.
Applicant Organization:  Massachusetts General Hospital (Boston, U.S.A.)
Project Title:  Chitinase 3-like proteins in colitis-associated carcinogenesis
Period of Award:  September 1, 2010 - August 31, 2011

Mizoguchi A, Mizoguchi E.  Animal models of IBD: linkage to human disease.  Current Opinion in Pharmacology 2010;10:578-87.

Aomatsu T, Imaeda H, Matsumoto K, Kimura E, Yoden A, Tamai H, Fujiyama Y, Mizoguchi E, Andoh A.  Faecal chitinase 3-like-1: a novel biomarker of disease activity in paediatric inflammatory bowel disease.  Alimentary Pharmacology & Therapeutics 2011;34:941-8.

Chen CC, Llado V, Eurich K, Tran HT, Mizoguchi E.  Carbohydrate-binding motif in chitinase 3-like 1 (CHI3L1/YKL-40) specifically activates Akt signaling pathway in colonic epithelial cells.  Clinical Immunology 2011;140:268-75.

Chen CC, Pekow J, Llado V, Kanneganti M, Lau CW, Mizoguchi A, Mino-Kenudson M, Bissonnette M, Mizoguchi E.  Chitinase 3-like-1 expression in colonic epithelial cells as a potentially novel marker for colitis-associated neoplasia.  American Journal of Pathology 2011;179:1494-503.

Kanneganti M, Mino-Kenudson M, Mizoguchi E.  Animal models of colitis-associated carcinogenesis.  Journal of Biomedicine and Biotechnology 2011;2011:342637.

Tran HT, Barnich N, Mizoguchi E.  Potential role of chitinases and chitin-binding proteins in host-microbial interactions during the development of intestinal inflammation.  Histology and Histopathology 2011;26:1453-64.