Grants Funded in 2011

Principal Investigator:  Chan, Andrew T., M.D., M.P.H.
Proposal No. IBD-0312R
Applicant Organization:  Massachusetts General Hospital (U.S.A.)
Project Title:  A prospective study of plasma vitamin D and risk of inflammatory bowel disease
Period of Award:  July 1, 2011 - December 31, 2012
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Principal Investigator:  Cohn, Steven M., M.D., Ph.D.
Proposal No. IBD-0314R
Applicant Organization:  University of Virginia (U.S.A.)
Project Title:  Role of RELMβ in the pathogenesis of IBD: effects on innate immune function and intestinal inflammation
Period of Award:  July 1, 2011 - June 30, 2012
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Principal Investigator:  Forbes, Geoffrey M., MBBS, M.D.
Proposal No. IBD-0313
Applicant Organization:  Royal Perth Hospital (Australia)
Project Title:  Mesenchymal stromal cells for treating refractory Crohn's disease
Period of Award:  February 1, 2011 - October 31, 2012
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Principal Investigator:  Hart, Ailsa L., MB ChB, Ph.D.
Proposal No. IBD-0322
Applicant Organization:  Imperial College London (England)
Project Title:  Immunological and microbiological effects of fecal transplantation in chronic pouchitis
Period of Award:  September 1, 2011 - August 31, 2012
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Principal Investigator:  Hommes, Daniel Willem, M.D., Ph.D.
Proposal No. IBD-0295R
Applicant Organization:  Leiden University Medical Center (Netherlands)
Project Title:  Therapeutic use of regulatory T cells in inflammatory bowel disease
Period of Award:  March 1, 2011 - February 28, 2012
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Principal Investigator:  Knowles, Simon R., Ph.D.
Proposal No. IBD-0293R
Applicant Organization:  Swinburne University of Technology (Australia)
Project Title:  IBDeTherapy: Development and validation of the world's first evidence-based, automated online program for the assessment and treatment of IBD-associated anxiety and depression
Period of Award:  January 1, 2011 - December 31, 2011
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Principal Investigator:  Kwon, John, M.D., Ph.D.
Proposal No. IBD-0321R
Applicant Organization:  The University of Chicago (U.S.A.)
Project Title:  Long non-coding RNA expression in IBD and modulation of microRNA-mediated inflammatory gene expression
Period of Award:  July 1, 2011 - December 31, 2012
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Principal Investigator:  Lawrance, Ian C., MBBS, Ph.D.
Proposal No. IBD-0325
Applicant Organization:  University of Western Australia (Australia)
Project Title:  A multi-centre double-blind randomized placebo-controlled study of the use of rectal tacrolimus in the treatment of resistant ulcerative proctitis
Period of Award:  November 1, 2011 - October 31, 2012
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Principal Investigator:  Levings, Megan K., Ph.D.
Proposal No. IBD-0326
Applicant Organization:  The University of British Columbia (Canada)
Project Title:  Flagellin-specific T cells in Crohn's disease
Period of Award:  November 1, 2011 - October 31, 2012
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Principal Investigator:  Nuñez, Gabriel, M.D.
Proposal No. IBD-0308R
Applicant Organization:  University of Michigan (U.S.A.)
Project Title:  A genome wide siRNA screen to identify regulators of NOD2 signaling
Period of Award:  January 1, 2011 - December 31, 2011
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Principal Investigator:  Ponsioen, Cyriel, M.D., Ph.D.
Proposal No. IBD-0302R
Applicant Organization:  Academic Medical Centre (Netherlands)
Project Title:  In-depth characterization of the mucosal microbiota in patients with Crohn’s disease using novel potent high-throughput approaches
Period of Award:  April 1, 2011 - March 31, 2013
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Principal Investigator:  Schmidt, M. Alexander, Ph.D.
Proposal No. IBD-0311R2
Applicant Organization:  University of Münster (Germany)
Project Title:  Characterization of the bacterial effector protein YopM as a cell-penetrating anti-inflammatory factor in experimental models of inflammatory bowel disease
Period of Award:  June 1, 2011 - May 31, 2013
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Principal Investigator:  Stagg, Andrew J., Ph.D.
Proposal No. IBD-0317R
Applicant Organization:  Queen Mary University of London (England)
Project Title:  Targeting intestinal retinoic acid availability as a therapy for inflammatory bowel diseases
Period of Award:  September 1, 2011 - August 31, 2012
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Principal Investigator:  Stylianou, Eleni, Ph.D.
Proposal No. IBD-0320R
Applicant Organization:  Cleveland Clinic Foundation (U.S.A.)
Project Title:  Epigenetic regulation of IBD-association fibrosis: potential for novel anti-fibrotic therapies
Period of Award:  October 1, 2011 - September 30, 2012
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Principal Investigator:  Xiong, Huabao, M.D., Ph.D.
Proposal No. IBD-0316R
Applicant Organization:  Mount Sinai School of Medicine (U.S.A.)
Project Title:  Silencing of the Th17 cell differentiation by transcription factor IRF8 in the development of colitis
Period of Award:  June 1, 2011 - November 30, 2012
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