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Second Annual BMRP Investigator Meeting

February 5-6, 2004
Los Angeles, California

(NOTE:  You must have Adobe Acrobat software in order to open the presentation documents.  Click here to download this free software.)
 


INVITED SPEAKERS:

Braun, Jonathan, M.D., Ph.D.
University of California, Los Angeles 
(U.S.A.)

"Being 10% human:  commensal microbiota and microbial-immune homeostasis"

Presentation

 


Fiocchi, Claudio, M.D.
Case Western Reserve University 
(Cleveland, Ohio, U.S.A.)

"Inflammatory bowel disease:  are we beginning to understand the "whys" and the "hows?"

Presentation
 


SCIENTIFIC SUMMARY OF MEETING:

Fiocchi, Claudio, M.D.
Case Western Reserve University 
(Cleveland, Ohio, U.S.A.)

Presentation
 


 


PRESENTATIONS BY BMRP INVESTIGATORS
(partial list of talks and posters)

Cartwright, Christine A., M.D.
Stanford University 
(California, U.S.A.)

"Ulcerative colitis:  molecular mechanisms of carcinogenesis"


 


Craig, Robert M., M.D.
Northwestern University 
(Chicago, Illinois, U.S.A.)

"Immune ablation and hematopoietic stem cell support in patients with severe Crohn's disease"

Abstract
Presentation

 


Cummins, Adrian, G., Ph.D., M.D.
The Queen Elizabeth Hospital 
(Woodville South, Australia)

"Va24+ T-cells are deficient and have defective interleukin-4 and interferon-
g production in inflammatory bowel disease"

Abstract
Presentation


Denson, Lee A., M.D.
Cincinnati Children's Hospital Medical Center (Ohio, U.S.A.) - current
Yale University (New Haven, Connecticut, U.S.A.) - original

"Growth hormone reduces colon STAT3 activation and improves disease activity in experimental colitis"

Abstract
Presentation


Esworthy, Robert S., Ph.D.
City of Hope National Medical Center 
(Duarte, California, U.S.A.)

"Barrier breakdown in mice deficient in antioxidant defenses leads to ilealcolitis"

Abstract

 


Fantuzzi, Giamila, Ph.D.
University of Colorado 
(Denver, U.S.A.)

"Role of leptin receptors expression on T lymphocytes in intestinal inflammation"

Abstract
Presentation
 


Freeze, Hudson H., Ph.D.
The Burnham Institute 
(La Jolla, California, U.S.A.)

"An anti-glycan antibody blocks colitis, cytokine production and induces apoptosis of activated macrophage"

Abstract
Presentation


Grisham, Matthew B., Ph.D.
Louisiana State University 
Health Sciences Center 

(Shreveport, U.S.A.)

"LFA-1 deficient T-cells fail to induce chronic colitis in an immune-based mouse model"

Abstract


Hale, Laura P., M.D., Ph.D.
Duke University 
(Durham, North Carolina, U.S.A.)

"Bromelain treatment of 
inflammatory bowel diseases"

Abstract

 


Hebert, Steven C., M.D.
Yale University 
(New Haven, Connecticut, U.S.A.)

"Dietary calcium, spermine or tryptophan supplementation reduces severity of Dextran Sulfate Sodium (DSS)-induced colitis in rats"

Abstract


Kim, Chang H., Ph.D.
Purdue University 
(West Lafayette, Indiana, U.S.A.)

"Chemokines in Crohn's disease"

 

 


Krissansen, Geoffrey W., Ph.D.
University of Auckland 
(New Zealand)

"Pattern recognition receptors as susceptibility loci for Crohn's disease"
 

 


Kucharzik, Torsten F., M.D.
University Hospital of Muenster 
(Germany)

"Antiinflammatory effects of alpha-melanocyte stimulating hormone (
a
-MSH) and its tripeptide KPV in inflammatory bowel disease animal models"

Abstract
Presentation


Mizoguchi, Emiko, M.D.
Massachusetts General Hospital 
(Boston, U.S.A.)

"The role of tumor necrosis factor receptors (TNFRs) of non-lymphoid cells under inflammatory condition"

Abstract


Monteleone, Giovanni, M.D., Ph.D.
Universita di Roma Tor Vergata 
(Rome, Italy)

"Role of SMAD7, an inhibitor of TGF-beta1
signaling, in chronic intestinal inflammation"


 


Newberry, Rodney, M.D.
Washington University 
(St. Louis, Missouri, U.S.A.)

"Post-gestational lymphotoxin/ lymphotoxin beta receptor 
interactions essential to the intestinal immune response"

Abstract


Rachmilewitz, Daniel, M.D.
Shaare Zedek Medical Center 
(Jerusalem, Israel)

"Toll R-9 signaling mediates the anti-inflammatory effect of probiotics in experimental colitis"

Abstract
Presentation


Shekels, Laurie L., Ph.D.
University of Minnesota 
(Minneapolis, U.S.A.)

"Does phosphorylation play a role in the function of the MUC3-related mucins?"

Abstract

 


Söderholm, Johan D., M.D., Ph.D.
Linköping University 
(Sweden)

"Role of the follicle-associated epithelium in the initiation of inflammatory bowel disease"

Abstract

 


Straus, Daniel S., Ph.D.
University of California, Riverside 
(U.S.A.)

"Studies on the therapeutic activity of PPARgamma ligands rosiglitazone and 15d-PG2 in mouse models 
for inflammatory bowel disease"

 


Summers, Robert W., M.D.
University of Iowa
(Iowa City, U.S.A.)

"Double-blind, placebo-controlled trial of
helminth ova therapy in active ulcerative colitis"

Abstract

 


Swidsinski, Alexander, M.D., Ph.D.
The University Hospital Charité of the Humboldt University of Berlin 
(Germany)

"A high bacteroids/erec ratio of the mucosal biofilm is a main feature in inflammatory bowel disease"

 


Vermeire, Severine, M.D.
Katholieke Universiteit Leuven 
(Belgium)

"Predictors of response to anti-TNF
a  
treatment in Crohn's disease"

Abstract
Presentation

 

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Goals

The BMRP funds innovative clinical or basic IBD research projects that are in the early stages of exploration and will benefit IBD patients.


Eli & Edythe L. Broad

The Broads are dedicated to advancing medical knowledge by funding innovative IBD research.


Daniel Hollander, M.D.

Dr. Hollander is the BMRP Director and a Professor of Medicine at UCLA.


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