Third Annual BMRP Investigator Meeting

February 24-25, 2005
Los Angeles, California

(NOTE:  You must have Adobe Acrobat software in order to open the presentation documents.  Click here to download this free software.)

INVITED SPEAKER:

Baltimore, David, Ph.D.
Nobel Laureate in Physiology or Medicine
President, California Institute of Technology 
(Pasadena, California, U.S.A.)
 
"NF-kappaB and its role in inflammation"
 

SCIENTIFIC SUMMARY OF MEETING:

Jewell, Derek, BM, BCh, DPhil
University of Oxford
(United Kingdom)
 

PRESENTATIONS BY BMRP INVESTIGATORS: 
(partial list of talks and posters)

Ahmad, Tariq, M.B. Ch.B.
University of Oxford 
(United Kingdom)

"Loop ileostomy for Crohn's disease - molecular clues to disease pathogenesis"

Abstract
 

Anderson, James, M.D., Ph.D.
University of North Carolina
at Chapel Hill 
(U.S.A.)

"The role of intestinal flora in transcriptional and  functional control
of the tight junction barrier"

Abstract

Baumgart, Daniel C., M.D.
Charité Medical Center - Virchow Hospital
(Germany)

"Patients with active inflammatory bowel disease lack immature peripheral blood dendritic cells that show an aberrant response to microbial surrogate stimuli"

Abstract

Bienenstock, John, M.D.
McMaster University
(Hamilton, Ontario, Canada)

"Is there a neurophysiologic basis for
 immunoregulation by probiotics?"

Braun, Jonathan, M.D., Ph.D.
University of California, Los Angeles
(U.S.A.)

"Intestinal fungal and bacterial
composition of the murine intestine"

Abstract
Presentation

Butler, Matthew, Ph.D.
Imperial College London
(United Kingdom)

"Effect of dietary microparticles on macrophage
function in Crohn's disease"

Abstract
 

Carrier, Ewa, M.D.
University of California, San Diego
(U.S.A.)

"Repair of Crohn's disease
with embryonic stem cells"

Abstract
 

Cartwright, Christine A., M.D.
Stanford University
(California, U.S.A.)

"Ulcerative colitis:  molecular
mechanisms of carcinogenesis"
 

Clancy, Robert, M.D., Ph.D.
University of Newcastle
(Australia)

"Mycobacterium avium subspecies paratuberculosis - does it have a role in the pathogenesis of Crohn's disease?"

Abstract

Colman, Robert W., M.D.
Temple University
(Philadelphia, Pennsylvania, U.S.A.)

"High molecular weight kininogen fragments  stimulate the secretion of interleukin 1b through urokinase-type plasminogen activation receptor (uPAR) and CD11b/CD18 (Mac-1) in human blood monocytes"

Abstract

Cummins, Adrian, G., Ph.D., M.D.
The Queen Elizabeth Hospital 
(Woodville South, Australia)

"Deficiency of NK and CD1d restricted Va24+ NK T-cells in Crohn's disease and ulcerative colitis"

Abstract

Denson, Lee A., M.D.
Cincinnati Children's Hospital Medical Center (Ohio, U.S.A.)

"Immunomodulatory effects of growth
hormone in experimental colitis"

Abstract

 

Florin, Timothy H. J., MBBS
University of Queensland 
(South Brisbane, Australia)

"Real-time PCR quantification of suspect bacteria in inflammatory bowel disease mucosa"

Abstract

Föll, Dirk, M.D.
University of Münster
(Germany)

"The role of the pro-inflammatory mediator
S100A12 in inflammatory bowel disease"

Abstract

Gewirtz, Andrew, Ph.D.
Emory University 
(Atlanta, Georgia, U.S.A.)

"Adaptive immunity to flagellin in
inflammatory bowel disease"

 Presentation

Ginsburg, Philip M., M.D.
Johns Hopkins University 
(Baltimore, Maryland, U.S.A.)

"Testing the homogeneity of the stenotic/stricturing phenotype in Crohn's disease utilizing PET/CT imaging"

Abstract

Greeley, George H., Jr., Ph.D.
University of Texas at Galveston
(U.S.A.)

"Increased colonic apelin expression during experimental colitis  in rodents and in humans with inflammatory bowel disease"

Abstract

Hale, Laura P., M.D., Ph.D.
Duke University 
(Durham, North Carolina, U.S.A.)

"Bromelain treatment of 
inflammatory bowel disease"

Abstract

Hanski, Christoph, Ph.D.
Charité Universitätsmedizin Berlin
Campus Benjamin Franklin
(Germany)

"Effects of deoxycholic acid and ursodeoxycholic acid on the development
of carcinomas during murine chronic ulcerative colitis"

Abstract

Hebert, Steven C., M.D.
Yale University 
(New Haven, Connecticut, U.S.A.)

"Activation of the extracellular calcium (nutrient)-sensing receptor reduces the severity of acute and chronic
DSS-induced injury"

Holcombe, Randall F., M.D.
University of California, Irvine 
(U.S.A.)

"WNT signaling in inflammatory bowel
disease-related colon cancer"

Abstract
 

Jobin, Christian, Ph.D.
University of North Carolina at Chapel Hill 
(U.S.A.)

"The flavonoid luteolin prevents LPS-induced NF-kB signaling  and gene expression by blocking IkB kinase activity in intestinal epithelial cells and bone marrow-derived dendritic cells"

Abstract
Presentation

Kobayashi, Koichi, M.D., Ph.D.
Harvard University
(Boston, Massachusetts, U.S.A.)

"A role of innate immunity in the pathogenesis
of inflammatory bowel disease"

Abstract
 

Koide, Yukio, M.D., Ph.D.
Hamamatsu University School of Medicine
(Japan)

"A randomized clinical trial of curcumin in
the maintenance therapy of ulcerative colitis"

Abstract
Presentation

Kucharzik, Torsten F., M.D.
University of Münster 
(Germany)

"Anti-inflammatory activity of the a-MSH
and its tripeptide KPV in inflammatory
bowel disease animal models"
 

Lamps, Laura W., M.D.
University of Arkansas for Medical Sciences
(Little Rock, U.S.A.)

"Pathogenic Yersinia DNA detection in Crohn's disease"

Abstract

Leiter, Edward H., Ph.D.
The Jackson Laboratory
(Bar Harbor, Maine, U.S.A.)

"Cdcs1, a major colitis susceptibility gene in mice, regulates innate and adaptive immune response to enteric bacterial antigens"

Abstract

Leung, Euphemia, Ph.D.
University of Auckland
(New Zealand)

"Alternative splicing of NOD2 (CARD15) RNA transcripts as a means of regulating the expression of human NOD2"

"Polymorphisms of CARD15/NOD2 and CD14
genes in New Zealand Crohn's disease patients"
 

Li, Xuhang, Ph.D.
Johns Hopkins University
(Baltimore, Maryland, U.S.A.)

"Quantitative proteomic studies of human inflammatory bowel disease"

Abstract

Maggio-Price, Lillian, V.M.D., Ph.D.
University of Washington
(Seattle, U.S.A.)

"Helicobacter infection synergizes with impaired TGFb signaling to induce colon cancer in mice deficient in SMAD3"

Abstract

Mangino, Martin J., Ph.D.
University of Wisconsin-Madison
(U.S.A.)

"Colonic lipoxin synthesis in patients and mice with inflammatory bowel disease"

Presentation

Mizoguchi, Emiko, M.D.
Massachusetts General Hospital 
(Boston, U.S.A.)

"Chitinase 3-like-1 (Chi3L1) exacerbates intestinal inflammation by enhancing intracellular bacterial adhesion and internalization in colonic epithelial cells"
 

Morales, Victor M., Ph.D.
Boston University Medical Center 
(Massachusetts, U.S.A.)

"New methods for identification of peptides that stimulate T cells isolated from Crohn's disease subjects"

Presentation

Morrison, Douglas, Ph.D.
University of Glasgow
(Scotland)

"Novel strategies for the colonic
provision of butyric acid"

Newberry, Rodney, M.D.
Washington University 
(St. Louis, Missouri, U.S.A.)

"Post-gestational lymphotoxin/ lymphotoxin
beta receptor interactions essential to the 
intestinal immune response"
 

Nuñez, Gabriel, M.D.
University of Michigan Medical School 
(Ann Arbor, U.S.A.)

"Nod2 is expressed in Paneth cells and regulates innate immunity to intracellular bacteria in the intestinal tract"

Presentation

Papadakis, Konstantinos A., M.D.
Cedars-Sinai Medical Center 
(Los Angeles, California, U.S.A.)

"Phenotypic and functional characterization of CCR9+ T lymphocytes in small intestinal Crohn's disease"

Abstract
Presentation

Plevy, Scott E., M.D.
University of Pittsburgh
(Pennsylvania, U.S.A.)

"Clostridium perfringens as a novel therapeutic vehicle in inflammatory bowel disease"

Abstract

Rampton, David S., BM, DPhil
Queen Mary, University of London
(United Kingdom)

"Stress, hypnosis and ulcerative colitis"

Abstract
Presentation
 

Rogler, Gerhard, M.D., Ph.D.
University of Regensburg
(Germany)

"Role of NOD2/CARD15 for oxidative burst reaction and NF-kB activation in intestinal macrophages"

Abstract
Presentation

Romagnuolo, Joseph, M.D.
University of Calgary
(Canada)

"Wireless capsule endoscopy and intestinal permeability in asymptomatic first-degree relatives of Crohn's patients"

Abstract

Rottiers, Pieter, Ph.D.
Ghent University
(Belgium)

"Treatment of experimental colitis by camelid antibody fragments:  local administration and evaluation of their therapeutic potential"
 

Rühl, Anne, M.D., Ph.D.
Technical University of Munich
(Germany)

"Enteric glia in intestinal inflammation"

Abstract
Presentation
 

Sano, Takeshi, Ph.D.
Beth Israel Deaconess Medical Center
(Boston, Massachusetts, U.S.A.)

"Colon-directed delivery of viral vectors using virus-microbead conjugates for gene therapy of inflammatory bowel disease"

Abstract

Semret, Makeda M.D.
McGill University
(Montreal, Quebec, Canada)

"Mycobacterium paratuberculosis in Crohn's:  a study using tissue PCR, in situ PCR and gamma-interferon responses"

Abstract
Presentation

Siegmund, Britta, M.D.
Charité Universitätsmedizin Berlin, Campus Benjamin Franklin
(Germany)

"Specific inhibition of histone deacetylases as novel anti-inflammatory and anti-proliferative approach in experimental colitis"

Abstract

Smyrk, Thomas C., M.D.
Mayo Clinic Rochester
(Minnesota, U.S.A.)

"HLA typing and expression:  marker for identifying dysplasia and stratifying the risk for IBD-cancer"

Abstract
Presentation

Söderholm, Johan D., M.D., Ph.D.
Linköping University 
(Sweden)

"Disrupted barrier to non-pathogenic E. coli
in the follicle-associated epithelium of non-
inflamed ileum of patients with Crohn's disease"

Abstract

Srikrishna, Geetha, Ph.D.
The Burnham Institute
(La Jolla, California, U.S.A.)

"Understanding the role of carboxylated glycans, RAGE and S100 proteins in molecular events leading to pathogenesis of colitis"
 

Stenson, William F., M.D.
Washington University
(St. Louis, Missouri, U.S.A.)

"CTLA-4 immunoglobulin fusion protein increases indoleamine-2,3-dioxygenase expression and diminishes the severity of TNBS colitis"

Abstract

Swidsinski, Alexander, M.D., Ph.D.
Charité Universitätsmedizin Berlin, Campus Charité-Mitte 
(Germany)

"Spatial organization and composition of the mucosal flora in inflammatory bowel disease"

Abstract

Tannock, Gerald W., Ph.D.
University of Otago
(Dunedin, New Zealand)

"Cloning the gut metagenome:  a strategy to detect pro-inflammatory substances produced by intestinal bacteria"

Abstract

Van Kruiningen, Herbert J.,
DVM, Ph.D., M.D.
University of Connecticut
(Storrs, U.S.A.)

"A PCR search for evidence of recurring
or persistent viruses in Crohn's disease"

Abstract

Wittig, Bianca M., M.D.
Charité Universitätsmedizin Berlin, Campus Benjamin Franklin
(Germany)

"Anti-CD44v7 antibody specifically induces the mitochondrial apoptosis pathway that is defective in Crohn's disease"

Abstract

Yacyshyn, Bruce R., M.D.
Case Western Reserve University
(Cleveland, Ohio, U.S.A.)

"C-methyl cellulose reduces inflammatory measurements in the HLA-B27 transgenic rat model of inflammatory bowel diseases"

Back to Top