BMRP Grants Funded in 2002

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Principal Investigator: Cummins, Adrian, M.D., Ph.D.

Proposal No. IBD-0029

Applicant Organization: The Queen Elizabeth Hospital (Australia)

Project Title: Deficiency of immunoregulatory NK T cells in inflammatory bowel disease

Award Period: November 1, 2002 - March 31, 2005

Principal Investigator: Danon, Stephen J., Ph.D.

Proposal No. IBD-0014

Applicant Organization: University of New South Wales (Australia)

Project Title: Immunization with mucous-associated bacteria of the intestine, including helicobacter species, as a novel approach to the prevention and amelioration of inflammatory bowel disease

Award Period: August 1, 2002 - July 31, 2003

Principal Investigator: Denson, Lee A., M.D.

Proposal No. IBD-0012R

Current Applicant Institution: Cincinnati Children's Hospital Medical Center (Ohio, U.S.A.)

Original Applicant Institution: Yale University (U.S.A.)

Project Title: Mechanisms of growth hormone resistance in experimental colitis

Award Period: October 1, 2002 - March 31, 2006

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Principal Investigator: Fantuzzi, Giamila, Ph.D.

Proposal No. IBD-0001

Applicant Organization: University of Colorado (U.S.A.)

Project Title: The leptin receptor: Role in inflammatory bowel disease

Award Period: January 1, 2002 - February 29, 2004

Principal Investigator: Florin, Timothy, MBBS

Proposal No. IBD-0032

Applicant Organization: The University of Queensland (Australia)

Project Title: Mucosal bacterial pathogens in inflammatory bowel disease

Award Period: December 1, 2002 - February 28, 2005

Principal Investigator: Freeze, Hudson, Ph.D.

Proposal No. IBD-0021

Applicant Organization: The Burnham Institute (U.S.A.)

Project Title: An anti-glycan antibody (mAbGB3.1) as a novel therapy for Crohn's disease and ulcerative colitis

Award Period: August 1, 2002 - March 31, 2005

Principal Investigator: Grisham, Matthew, Ph.D.
Proposal No. IBD-0002
Applicant Organization: Louisiana State University (U.S.A.)
Project Title: Role of the collagen-binding integrin alpha 1, beta 1 in an immune-based model of chronic colitis
Award Period: March 1, 2002 - February 29, 2004
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Principal Investigator: Hale, Laura P., M.D., Ph.D.

Proposal No. IBD-0024R

Applicant Organization: Duke University (U.S.A.)

Project Title: Bromelain treatment of inflammatory bowel disease

Award Period: December 1, 2002 - February 28, 2005

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Principal Investigator: Krissansen, Geoffrey W., Ph.D.

Proposal No. IBD-0003R

Applicant Organization: University of Auckland (New Zealand)

Project Title: Pattern recognition receptors as potential susceptibility loci for Crohn's disease

Award Period: November 1, 2002 - March 31, 2005

Principal Investigator: Meltzer, Stephen J., M.D.

Proposal No. IBD-0010

Applicant Institution: University of Maryland (U.S.A.)

Project Title: New approaches to inflammatory bowel disease-associated malignancy

Award Period: July 1, 2002 - June 30, 2004

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Principal Investigator: Monteleone, Giovanni, M.D., Ph.D.

Proposal No. IBD-0020R

Applicant Institution: University Tor Vergata of Rome (Italy)

Project Title: Role of Smad7, an inhibitor of TGF-beta1 signaling, in chronic intestinal inflammation

Award Period: September 1, 2002 - November 30, 2004

Principal Investigator: Omary, M. Bishr, Ph.D., M.D.

Proposal No. IBD-0006

Applicant Organization: Stanford University (U.S.A.)

Project Title: Keratin mutations as a risk factor for inflammatory bowel disease

Award Period: April 1, 2002 - September 30, 2003

Principal Investigator: Peng, Stanford, M.D., Ph.D.

Proposal No. IBD-0035

Applicant Institution: Washington University (U.S.A.)

Project Title: The roles of NFATs and innate immunity in intestinal inflammation

Award Period: October 1, 2002 - September 30, 2003

Principal Investigator: Rachmilewitz, Daniel, M.D.

Proposal No. IBD-0037

Applicant Institution: Shaare Zedek Medical Centre (Israel)

Project Title: Immunostimulatory DNA for the treatment of inflammatory bowel disease

Award Period: December 1, 2002 - November 30, 2004

Principal Investigator: Rutgeerts, Paul J., M.D., Ph.D.

Proposal No. IBD-0016

Applicant Organization: Katholieke Universiteit Leuven (Belgium)

Project Title: Study on genetic, immunological and serological predictors of response to anti-TNF alpha treatment in Crohn's disease

Award Period: December 1, 2002 - November 30, 2003

Principal Investigator: Saubermann, Lawrence J., M.D.

Proposal No. IBD-0017

Applicant Organization: Boston Medical Center (U.S.A.)

Project Title: Immune modulation effects of PPARgamma in inflammatory bowel disease

Award Period: August 1, 2002 - July 31, 2004

Principal Investigator: Shekels, Laurie L., Ph.D.
Proposal No. IBD-0026
Applicant Organization: University of Minnesota (U.S.A.)
Project Title: Does phosphorylation play a role in the function of the MUC3-related mucins?
Award Period: November 1, 2002 - February 29, 2004
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Principal Investigator: Söderholm, Johan, M.D., Ph.D.

Proposal No. IBD-0007

Applicant Organization: Linköping University (Sweden)

Project Title: The role of the follicle-associated epithelium in the initiation of inflammatory bowel disease

Award Period: November 1, 2002 - September 30, 2005

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Principal Investigator: Straus, Daniel S., Ph.D.

Proposal No. IBD-0013

Institution: University of California, Riverside (U.S.A.)

Project Title: Trial of anti-inflammatory prostaglandins for treatment of inflammatory bowel disease in IL-10 knockout mice

Award Period: August 1, 2002 - July 31, 2004

Principal Investigator: Summers, Robert W., M.D.

Proposal No. IBD-0005

Applicant Institution: University of Iowa (U.S.A.)

Project Title: A controlled clinical trial of Trichuris suis in the therapy of active ulcerative colitis

Award Period: July 1, 2002 - December 31, 2003

Principal Investigator: van Deventer, Sander, Ph.D., M.D.

Proposal No. IBD-0008

Applicant Organization: Academic Medical Centre Medical Research B.V. (The Netherlands)

Project Title: Treatment of Crohn's disease by Lactococcus lactis secreting human IL-10

Award Period: December 1, 2002 - November 30, 2003

Principal Investigator: Van Kruiningen, Herbert J., DVM, Ph.D., M.D.

Proposal No. IBD-0044

Applicant Institution: University of Connecticut (U.S.A.)

Project Title: Epidemiology of familial Crohn's disease

Award Period: December 1, 2002 - March 31, 2006

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Principal Investigator: Van Parijs, Luk, Ph.D.

Proposal No. IBD-0025

Applicant Institution: Massachusetts Institute of Technology (U.S.A.)

Project Title: Control of regulatory T cell activity and inflammatory bowel disease by interleukin-2

Award Period: October 1, 2002 - September 30, 2003

Principal Investigator: Wallace, Michael B., M.D., MPH

Proposal No. IBD-0015R

Applicant Organization: Medical University of South Carolina (U.S.A.)

Project Title: Evaluation of spectroscopy for the detection of dysplasia in interleukin-10 -deficient mice with enterocolitis - a pilot study

Award Period: December 1, 2002 - August 26, 2003