BMRP Grants Funded in 2004

Project Title: Mycobacterium avium paratuberculosis (MAP) plays a critical role in the pathogenesis of Crohn’s disease in a substantial proportion of subjects

Period of Award: April 19, 2004 – April 30, 2006

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Principal Investigator: Colman, Robert W., M.D.

Proposal No. IBD-0080R

Applicant Organization: Temple University (U.S.A.)

Project Title: Kallikrein-kinin system in inflammatory bowel disease

Period of Award: January 1, 2004 - December 31, 2006

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Principal Investigator: Gewirtz, Andrew T., Ph.D.

Proposal No. IBD-0102

Applicant Organization: Emory University (U.S.A.)

Project Title: Adaptive immunity to flagellin in inflammatory bowel disease

Period of Award: May 1, 2004 – April 30, 2006

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Principal Investigator: Greeley, George H., Jr., Ph.D.

Proposal No. IBD-0118

Applicant Organization: The University of Texas Medical Branch (U.S.A.)

Project Title: Protective and repair action of apelin, a new enteric protein, on the intestinal mucosa in experimental colitis

Period of Award: June 1, 2004 – September 30, 2006

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Principal Investigator: Hanski, Christoph, Ph.D.

Proposal No. IBD-0099R

Applicant Organization: Charité Universitätsmedizin Berlin, Campus Benjamin Franklin (Germany)

Project Title: Effects of deoxycholic acid and ursodeoxycholic acid on the development of carcinomas during chronic ulcerative colitis: proof of principle in an animal model

Period of Award: March 1, 2004 – June 30, 2006

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Principal Investigator: Hershberg, Robert, M.D., Ph.D.

Proposal No. NICE-08

Applicant Institution: University of Washington (U.S.A.)

Project Title: Therapeutic modulation of flagellin responses in inflammatory bowel disease

Award Period: January 1, 2004 - June 30, 2006

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Principal Investigator: Jobin, Christian, Ph.D.

Proposal No. IBD-0116R

Applicant Organization: University of North Carolina at Chapel Hill (U.S.A.)

Project Title: Modulation of innate signal transduction and experimental colitis by natural plant extracts

Period of Award: July 1, 2004 - December 31, 2005

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Principal Investigator: Koide, Yukio, M.D., Ph.D.

Proposal No. IBD-0069R2

Applicant Organization: Hamamatsu University (Japan)

Project Title: A randomized clinical trial of curcumin in the therapy of ulcerative colitis

Period of Award: January 1, 2004 - September 30, 2006

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Principal Investigator: Kwon, John H., M.D., (replacement PI);

Ginsburg, Philip M., M.D. (original PI)

Proposal No. IBD-0122R

Applicant Organization: Johns Hopkins University (U.S.A.)

Project Title: Differentiating fibrostenosing from inflammatory small bowel disease in patients with Crohn’s disease using combined ¹⁸F-fluorodeoxyglucose positron emission tomography and computed tomography

Period of Award: September 1, 2004 – December 31, 2005

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Principal Investigator: Lamps, Laura W., M.D.

Proposal No. IBD-0095

Applicant Institution: University of Arkansas for Medical Sciences (U.S.A.)

Project Title: Pathogenic Yersinia DNA detection in Crohn's disease

Award Period: January 1, 2004 - March 31, 2006

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Principal Investigator: Leiter, Edward, Ph.D.

Proposal No. IBD-0104

Applicant Organization: The Jackson Laboratory (U.S.A.)

Project Title: Functional genomics of colitis susceptibility in IL-10 deficient mice

Period of Award: March 1, 2004 – June 30, 2006

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Principal Investigator: Levi, Ben-Zion, Ph.D.

Proposal No. IBD-0125P

Applicant Organization: Technion - Israel Institute of Technology (Israel)

Project Title: Association between Nramp1 polymorphisms and Crohn’s disease in Israeli Jewish population

Period of Award: August 1, 2004 – July 31, 2005

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Principal Investigator: Maggio-Price, Lillian, V.M.D., Ph.D.

Proposal No. IBD-0106

Applicant Organization: University of Washington (U.S.A.)

Project Title: Molecular mechanism of colon carcinogenesis: collaborative effects of Helicobacter infection and TGF-b dysregulation

Period of Award: May 1, 2004 – November 30, 2006

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Principal Investigator: Mangino, Martin J., Ph.D.

Proposal No. IBD-0081R

Applicant Organization: University of Wisconsin-Madison (U.S.A.)

Project Title: Lipoxin metabolism in inflammatory bowel disease

Period of Award: February 1, 2004 - April 30, 2006

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Principal Investigator: Michel, Klaus, Ph.D. (replacement PI);

Rühl, Anne, M.D., Ph.D. (original PI)

Proposal No. IBD-0105R

Applicant Organization: Technische Universität München (Germany)

Project Title: Enteric glia in intestinal inflammation

Period of Award: July 1, 2004 – June 30, 2006

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Principal Investigator: Morales, Victor M., Ph.D.

Proposal No. IBD-0094

Applicant Organization: University of Rochester (replacement organization - U.S.A.)

Boston University Medical Center (original organization - U.S.A.)

Project Title: Peptides recognized by T cell clones from inflammatory bowel disease patients

Period of Award: February 1, 2004 - September 30, 2006

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Principal Investigator: Nuñez, Gabriel, M.D.

Proposal No. IBD-0091R

Applicant Organization: University of Michigan (U.S.A.)

Project Title: Role of Nod2 in the control of Paneth cell function and intestinal microflora

Award Period: May 1, 2004 - May 31, 2006

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Principal Investigator: Ortner, Maria-Anna, M.D.

Proposal No. IBD-0088

Applicant Organization: Centre Hospitalier Universitaire Vaudois (Switzerland)

Project Title: Photodynamic therapy in Crohn’s disease

Period of Award: February 1, 2004 - June 30, 2006

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Principal Investigator: Papadakis, Konstantinos, M.D.

Proposal No. IBD-0092R

Applicant Organization: Cedars-Sinai Medical Center (U.S.A.)

Project Title: Phenotypic and functional characterization of CCR9+ T lymphocytes in small intestinal Crohn’s disease

Period of Award: April 1, 2004 – December 31, 2005

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Principal Investigator: Pender, Sylvia Lin Foon, Ph.D.

Proposal No. IBD-0064

Applicant Organization: University of Southampton (United Kingdom)

Project Title: Functional role of human macrophage metalloelastase in inflammatory bowel disease

Period of Award: January 1, 2004 – August 31, 2007

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Principal Investigator: Phanstiel, Otto, Ph.D.

Proposal No. IBD-0090R

Applicant Organization: University of Central Florida (U.S.A.)

Project Title: Development of polyamine conjugates as sensitive probes to explore inflammatory bowel disease processes

Period of Award: May 1, 2004 - February 28, 2007

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Principal Investigator: Plevy, Scott, M.D.

Proposal No. IBD-0110

Applicant Organization: University of Pittsburgh (U.S.A.)

Project Title: Clostridium perfringens as a novel therapeutic vehicle in inflammatory bowel disease

Period of Award: August 1, 2004 - January 31, 2006

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Principal Investigator: Rottiers, Pieter, Ph.D. (replacement PI)Cuvelier, Claude, M.D., Ph.D. (original PI)

Proposal No. IBD-0123

Applicant Organization: Flanders Interuniversity Institute for Biotechnology vzw (replacement organization - Belgium)
Ghent University (original organization - Belgium)

Project Title: Treatment of experimental colitis by camelid antibody fragments: local delivery by genetically engineered lactococci administration and evaluation of their therapeutic potential

Period of Award: July 1, 2004 - June 30, 2006

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Principal Investigator: Siegmund, Britta, M.D.

Proposal No. IBD-0108

Applicant Organization: Charité Universitätsmedizin Berlin, Campus Benjamin Franklin (Germany)

Project Title: Specific inhibition of histone deacetylases as a novel anti-inflammatory and anti-proliferative approach in experimental colitis in mice

Period of Award: April 1, 2004 – July 31, 2006

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Principal Investigator: Smyrk, Thomas C., M.D.

Proposal No. IBD-0075R2

Applicant Organization: Mayo Clinic Rochester (U.S.A.)

Project Title: HLA typing and expression: potential marker for identifying early dysplasia and stratifying the risk for inflammatory bowel disease-cancer

Period of Award: July 15, 2004 – May 31, 2007

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As of October 26, 2007

Letter of Interest

The first step in applying is to submit a Letter of Interest (LOI). Investigators whose LOIs fit the BMRP's criteria and interest areas will be invited to submit a full grant application.

Review Process

A committee does not review or make decisions on proposals. Leading investigators in each research area provide individual reviews and suggestions to improve the proposals.

Funded Grants

Review the list of funded grants before you submit a LOI. Included are scientific abstracts, lay summaries, presentations made at BMRP Investigator meetings, publications resulting from BMRP funding and final technical progress reports.

BMRP Statistics

See data on Principal Investigators, amounts awarded, etc.

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